1239691-88-3

Basic information

• Product Name: N-phenyl-2-(p-methoxybenzyl)piperidine
• Synonyms: N-phenyl-2-(p-methoxybenzyl)piperidine
• CAS NO: 1239691-88-3
• Molecular Weight: 281.398
• Mol File: 1239691-88-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-phenyl-2-(p-methoxybenzyl)piperidine(CAS DataBase Reference)
• NIST Chemistry Reference: N-phenyl-2-(p-methoxybenzyl)piperidine(1239691-88-3)
• EPA Substance Registry System: N-phenyl-2-(p-methoxybenzyl)piperidine(1239691-88-3)

Safety Data

• Hazardous Substances Data: 1239691-88-3(Hazardous Substances Data)

Upstream product

• 104-92-7 1-bromo-4-methoxy-benzene 
• 105971-30-0 hex-5-enyl-phenyl-amine 

Relevant articles and documents

On the scope of Pd-catalyzed carboamination reactions - Synthesis of 2,4-disubstituted pyrrolidines and 2-substituted piperidines and morpholines

The scope of the palladium-catalyzed carboamination reaction for the synthesis of 2-substituted pyrrolidines, piperidines, and morpholines was investigated. Formation of a 2,4-disubstituted pyrrolidine proceeded in high yield but with a diastereoisomeric ratio of only 2:5, favoring the cis-isomer. The diastereoselectivity is hence significantly smaller than that observed previously in the formation of 2,3- and 2,5-disubstituted pyrrolidines. The yields of substituted piperidines and morpholines were lowered by competing Heck arylation reactions. Both the N-substituent and the choice of phosphine ligand for the palladium-catalyzed reaction were determining for the outcome. The scope of the palladium-catalyzed carboamination reaction for the synthesis of 2-substituted pyrrolidines, piperidines, and morpholines was investigated.