1239897-01-8

Basic information

• Product Name: (2R)-2-methyl-N-[N-phthaloyl-(2S)-2-phenylglycyl]-1,2,3,4-tetrahydroquinoline
• Synonyms: (2R)-2-methyl-N-[N-phthaloyl-(2S)-2-phenylglycyl]-1,2,3,4-tetrahydroquinoline
• CAS NO: 1239897-01-8
• Molecular Weight: 410.472
• Mol File: 1239897-01-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2R)-2-methyl-N-[N-phthaloyl-(2S)-2-phenylglycyl]-1,2,3,4-tetrahydroquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: (2R)-2-methyl-N-[N-phthaloyl-(2S)-2-phenylglycyl]-1,2,3,4-tetrahydroquinoline(1239897-01-8)
• EPA Substance Registry System: (2R)-2-methyl-N-[N-phthaloyl-(2S)-2-phenylglycyl]-1,2,3,4-tetrahydroquinoline(1239897-01-8)

Safety Data

• Hazardous Substances Data: 1239897-01-8(Hazardous Substances Data)

Upstream product

• 1239896-95-7 N-phthaloyl-(S)-2-phenylglycyl chloride 
• 1780-19-4 1,2,3,4-tetrahydro-2-methylquinoline 
• 1780-19-4 (R)-1,2,3,4-tetrahydroquinaldine 

Relevant articles and documents

Acylative kinetic resolution of racemic amines using N-phthaloyl-(S)-amino acyl chlorides

A comparative study of the kinetic resolution of racemic 2-methyl-1,2,3,4-tetrahydroquinoline and 2,3-dihydro-3-methyl-4H-1,4-benzoxazine using N-phthaloyl-(S)-amino acyl chlorides as chiral acylating agents is described. Temperature and solvent effects on the stereochemical features have been examined. It has been found that N-phthaloyl-(S)-phenylalanyl and N-phthaloyl-(S)-2-phenylglycyl chlorides bearing aromatic substituents close to the stereogenic centre are more stereoselective acylating agents than N-phthaloyl-(S)-alanyl chloride. For the preparative kinetic resolution of racemic amines N-phthaloyl-(S)-phenylalanyl chloride proved to be the most appropriate chiral acylating agent.