123997-26-2 Usage
Description
Eprinomectin is a semisynthetic avermectin that consists of a mixture of two homologues, eprinomectin B1a (4 epi-acetylamino-4 -deoxy-avermectin B1; 90%) and eprinomectin B1b (10%). It is a crystalline solid with anthelmintic and insecticidal activities. Eprinomectin was developed as a topical endectocide for all categories of cattle, including lactating dairy cattle, and has a low milk:plasma partitioning ratio (<0.2) compared to ivermectin, which partitions equally between milk and plasma.
Used in Veterinary Medicine:
Eprinomectin is used as a topical endectocide (insecticide, miticide, and nematocide) for cattle, including lactating dairy cows. It is effective in reducing worm burden by 99% or more in bovine models of various endoparasites and ectoparasites, such as adult H. placei, O. ostertagi, T. axei, Cooperia punctata, N. helvetianus, O. radiatum, or D. viviparus infection. It also reduces parasite burden in bovine models of horn fly (H. irritans) or mange mite (C. bovis) infestation, as well as in cows naturally infested with lice (L. vituli), when applied topically at doses ranging from 0.16 to 0.5 mg/kg.
Eprinomectin acts by binding to parasite glutamate-gated chloride ion channels and disrupts neurotransmission, leading to paralysis and death of the parasite, mite, or insect. Formulations containing eprinomectin have been used in the treatment and control of a variety of endoand ectoparasites in cattle.
Brand Name:
Eprinex (Merial) is the brand name for eprinomectin in the veterinary market.
Veterinary Drugs and Treatments
In cattle, eprinomectin is indicated for a variety gastrointestinal
roundworms including
adult and L4 stages of Haemonchus placei,
Ostertagia ostertagi, Trichostrongylus axei and colubriformis,
Cooperia oncophora/punctata/surnabada, Nematodirus helvetianus,
Oesophagostomum radiatum, Bunostomum phlebotomum, and
Trichuris spp. (adults only); cattle grubs; lice; mange mites; horn
flies (for 7 days after treatment), and lungworms (Dictyocaulus
vivaparus—for 21 days after treatment).
Topical eprinomectin may be useful for the topical treatment
of ear mites (Psoroptes cuniculi) in rabbits. One small study (6 subjects)
showed partial response when rabbits were dosed at 5 mg/kg
topically, twice at 14 day intervals. (Ulutas, Voyvoda et al. 2005)
Toxicity evaluation
Acute oral LD50 for rats: 55mg/kg
Check Digit Verification of cas no
The CAS Registry Mumber 123997-26-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,3,9,9 and 7 respectively; the second part has 2 digits, 2 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 123997-26:
(8*1)+(7*2)+(6*3)+(5*9)+(4*9)+(3*7)+(2*2)+(1*6)=152
152 % 10 = 2
So 123997-26-2 is a valid CAS Registry Number.
InChI:InChI=1/C50H75NO14/c1-12-26(2)45-29(5)18-19-49(65-45)24-36-21-35(64-49)17-16-28(4)44(27(3)14-13-15-34-25-58-47-43(53)30(6)20-37(48(54)61-36)50(34,47)55)62-41-23-39(57-11)46(32(8)60-41)63-40-22-38(56-10)42(31(7)59-40)51-33(9)52/h13-16,18-20,26-27,29,31-32,35-47,53,55H,12,17,21-25H2,1-11H3,(H,51,52)/b14-13+,28-16+,34-15+/t26-,27-,29-,31-,32-,35+,36-,37-,38-,39-,40-,41-,42+,43+,44-,45+,46-,47+,49+,50+/m0/s1
