1240479-07-5 Usage
Description
N-5-Carboxypentyl-1-deoxygalactonojirimycin is a pale yellow solid that serves as a valuable ligand in the development of affinity resins for the purification of glucosidase I. N-5-Carboxypentyl-1-deoxygalactonojirimycin plays a crucial role in the post-translational processing of N-linked glycoproteins, making it an essential component in various biotechnological and pharmaceutical applications.
Uses
Used in Biotechnological Applications:
N-5-Carboxypentyl-1-deoxygalactonojirimycin is used as a ligand for the preparation of an affinity resin highly specific for glucosidase I purification. This enzyme is involved in the post-translational processing of N-linked glycoproteins, which is a critical step in the production of therapeutic proteins and the study of protein folding and stability.
Used in Pharmaceutical Applications:
N-5-Carboxypentyl-1-deoxygalactonojirimycin is used as a key component in the development of novel drug delivery systems. Its ability to selectively bind to glucosidase I allows for targeted delivery of therapeutic agents, improving the efficacy and reducing the side effects of various treatments.
Used in Research Applications:
N-5-Carboxypentyl-1-deoxygalactonojirimycin is used as a research tool for studying the role of glucosidase I in the post-translational processing of N-linked glycoproteins. N-5-Carboxypentyl-1-deoxygalactonojirimycin helps researchers gain a deeper understanding of protein folding, stability, and the mechanisms underlying various diseases, ultimately contributing to the development of new therapeutic strategies.
Check Digit Verification of cas no
The CAS Registry Mumber 1240479-07-5 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,4,0,4,7 and 9 respectively; the second part has 2 digits, 0 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1240479-07:
(9*1)+(8*2)+(7*4)+(6*0)+(5*4)+(4*7)+(3*9)+(2*0)+(1*7)=135
135 % 10 = 5
So 1240479-07-5 is a valid CAS Registry Number.
1240479-07-5Relevant articles and documents
1-Deoxy-d-galactonojirimycins with dansyl capped N-substituents as β-galactosidase inhibitors and potential probes for GM1 gangliosidosis affected cell lines
Fr?hlich, Richard F.G.,Furneaux, Richard H.,Mahuran, Don J.,Saf, Robert,Stütz, Arnold E.,Tropak, Michael B.,Wicki, Jacqueline,Withers, Stephen G.,Wrodnigg, Tanja M.
, p. 1592 - 1598 (2011/08/22)
Two simple and reliably accessible intermediates, N-carboxypentyl- and N-aminohexyl-1-deoxy-d-galactonojirimycin were employed for the synthesis of a set of terminally N-dansyl substituted derivatives. Reaction of the terminal carboxylic acid of N-carboxypentyl-1-deoxy-d-galactonojirimycin with N-dansyl-1,6-diaminohexane provided the chain-extended fluorescent derivative. Employing bis(6-dansylaminohexyl)amine, the corresponding branched di-N-dansyl compound was obtained. Partially protected N-aminohexyl-1-deoxy-d- galactonojirimycin served as intermediate for two additional chain-extended fluorescent 1-deoxy-d-galactonojirimycin (1-DGJ) derivatives featuring terminal dansyl groups in the N-alkyl substituent. These new compounds are strong inhibitors of d-galactosidases and may serve as leads en route to pharmacological chaperones for GM1-gangliosidosis.
