1240483-57-1Relevant articles and documents
N-Heterocyclic Carbene/Potassium Ion Cooperatively Catalyzed Phenylation Reactions of α,β-Unsaturated Acylazoliums
Zheng, Jinhua,Zhu, Kejie,Yuan, Yaofeng,Cheng, Jiajia
, p. 4569 - 4576 (2016/09/24)
A catalytic phenylation reaction of α,β-unsaturated acylazoliums with in-situ-generated phenolates was developed. A combination of N-heterocyclic carbene and potassium ion cooperatively catalyzed the generation of α,β-unsaturated acylazoliums and phenolates from α,β-unsaturated phenolic esters for the efficient [3+3] annulation, which involves a dearomatization–rearomatization process. The approach gives good yields and excellent regioselectivities, and the products could be easily converted into high-value polycyclic derivatives. Mechanistic studies demonstrated that the potassium ion plays a vital role in this reaction.
