1240718-47-1

Basic information

• Product Name: C₁₂H₁₃N
• CAS NO: 1240718-47-1
• Molecular Weight: 171.242
• Mol File: 1240718-47-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₂H₁₃N(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₂H₁₃N(1240718-47-1)
• EPA Substance Registry System: C₁₂H₁₃N(1240718-47-1)

Safety Data

• Hazardous Substances Data: 1240718-47-1(Hazardous Substances Data)

Upstream product

• 5779-93-1 2,3-dimethylbenzaldehyde 
• 2450-71-7 Propargylamine 

Relevant articles and documents

Monoamine oxidase inhibitors: Benzylidene-prop-2-ynyl-amines analogues

A new series of benzylidene-prop-2-ynyl-amines analogues have been synthesized and evaluated for their monoamine oxidase A and B inhibitory activity by determination of IC50 and selectivity index (SI). Among these inhibitors, benzhydrylidene-prop-2-ynyl-amine (2, IC50 32nM) and (3, 4-dimethoxy-benzylidene)-prop-2-ynylamine (10, IC50 14nM) provide the highest inhibitory potency toward monoamine oxidase (MAO) A and B respectively. (3,5-Dimethyl-1H-pyrrol-2-ylmethylene)-prop-2-ynyl-amine (1, SI=58.96) and compound (2, SI=0.34) were proved to be the superior selective inhibitors toward MAO-A and MAO-B respectively. Docking studies show that the imine moiety is located in hydrophobic pocket, bringing the propargyl group close to FAD which indicates that the different inhibitory potency toward MAO-A may be ascribable to both the distance between alkynyl group and N5 of FAD, and hydrogen bonding interactions between inhibitors and enzymes.