1240737-18-1Relevant articles and documents
Sulfoxides: Potent co-crystal formers
Eccles, Kevin S.,Elcoate, Curtis J.,Stokes, Stephen P.,Maguire, Anita R.,Lawrence, Simon E.
scheme or table, p. 4243 - 4245 (2011/12/22)
The design of co-crystals requires knowledge of robust supramolecular synthons. The sulfoxide is a potent hydrogen bond acceptor and has been used as a co-crystal former with a range of NH functional groups, via N-H...O S hydrogen bonds. The NH functional group retains favorable hydrogen bond motifs from its own structure in all cases where this is possible, with the sulfoxide interacting in a discrete, capping fashion in four cases and in a bifurcated, bridging fashion in the three other cases presented here.
