1242436-69-6

Basic information

• Product Name: N-{1-[3-(3-oxo-2,3-dihydro-benzo[1,4]oxazin-4-yl)-propyl]-piperidin-4-yl}-benzamide
• CAS NO: 1242436-69-6
• Molecular Weight: 393.486
• Mol File: 1242436-69-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-{1-[3-(3-oxo-2,3-dihydro-benzo[1,4]oxazin-4-yl)-propyl]-piperidin-4-yl}-benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-{1-[3-(3-oxo-2,3-dihydro-benzo[1,4]oxazin-4-yl)-propyl]-piperidin-4-yl}-benzamide(1242436-69-6)
• EPA Substance Registry System: N-{1-[3-(3-oxo-2,3-dihydro-benzo[1,4]oxazin-4-yl)-propyl]-piperidin-4-yl}-benzamide(1242436-69-6)

Safety Data

• Hazardous Substances Data: 1242436-69-6(Hazardous Substances Data)

Upstream product

• 1094435-32-1 4-(3-bromopropyl)-2H-benzo[b][1,4]oxazin-3(4H)-one 
• 33953-37-6 N-(piperidin-4-yl)benzamide 

Relevant articles and documents

Discovery of N-{1-[3-(3-Oxo-2,3-dihydrobenzo[1,4]oxazin-4-yl)propyl] piperidin-4-yl}-2-phenylacetamide (Lu AE51090): An allosteric muscarinic M 1 receptor agonist with unprecedented selectivity and procognitive potential

The discovery and Structure-activity relationship (SAR) of a series of allosteric muscarinic M1 receptor agonists are described. Compound 17 (Lu AE51090) was identified as a representative compound from the series, based on its high selectivity as an agonist at the muscarinic M1 receptor across a panel of muscarinic receptor subtypes. Furthermore, 17 displayed a high degree of selectivity when tested in a broad panel of G-protein-coupled receptors, ion channels, transporters, and enzymes, and 17 showed an acceptable pharmacokinetic profile and sufficient brain exposure in rodents in order to characterize the compound in vivo. Hence, in a rodent model of learning and memory, 17 reversed delay-induced natural forgetting, suggesting a procognitive potential of 17.