1242441-07-1

Basic information

• Product Name: (1S,2S)-2-(4-{5-[(5-chloropyridin-2-yl)thio]-1-methyl-1H-imidazol-4-yl}phenyl)cyclopropanecarboxylic acid
• Synonyms: (1S,2S)-2-(4-{5-[(5-chloropyridin-2-yl)thio]-1-methyl-1H-imidazol-4-yl}phenyl)cyclopropanecarboxylic acid
• CAS NO: 1242441-07-1
• Molecular Weight: 385.874
• Mol File: 1242441-07-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (1S,2S)-2-(4-{5-[(5-chloropyridin-2-yl)thio]-1-methyl-1H-imidazol-4-yl}phenyl)cyclopropanecarboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (1S,2S)-2-(4-{5-[(5-chloropyridin-2-yl)thio]-1-methyl-1H-imidazol-4-yl}phenyl)cyclopropanecarboxylic acid(1242441-07-1)
• EPA Substance Registry System: (1S,2S)-2-(4-{5-[(5-chloropyridin-2-yl)thio]-1-methyl-1H-imidazol-4-yl}phenyl)cyclopropanecarboxylic acid(1242441-07-1)

Safety Data

• Hazardous Substances Data: 1242441-07-1(Hazardous Substances Data)

Upstream product

• 16110-09-1 2,5 dichloropyridine 
• 2039-82-9 1-bromo-4-ethenyl-benzene 
• 1242441-17-3 (1S,2S)-ethyl 2-(4-(5-((5-chloropyridin-2-yl)thio)-1-methyl-1H-imidazol-4-yl)phenyl)cyclopropanecarboxylate 
• 40771-41-3 2-mercapto-5-chloro-pyridine 
• 1242441-05-9 ethyl (1S,2S)-2-[4-(5-iodo-1-methyl-1H-imidazol-4-yl)phenyl]cyclopropanecarboxylate 
• 1242441-06-0 (1S,2S)-ethyl 2-(4-(1-methyl-1H-imidazol-4-yl)phenyl)cyclopropanecarboxylate 
• 875479-34-8 ethyl trans-2-(4-bromophenyl)cyclopropane-1-carboxylate 

Downstream Products

• 1242441-26-4 (1S,2S)-2-(4-(5-((5-chloropyridin-2-yl)thio)-1-methyl-1H-imidazol-4-yl)phenyl)-N,N-dimethylcyclopropanecarboxamide 
• 1242441-50-4 methyl (1S,2S)-2-(4-(5-((5-chloropyridin-2-yl)thio)-1-methy-1H-imidazol-4-yl)phenyl)cyclopropanecarboxylate 
• 1242441-32-2 (1S,2S)-2-(4-{5-[(5-chloropyridin-2-yl)thio]-1-methyl-1H-imidazol-4-yl}phenyl)-N-(2-fluoroethyl)-N-methylcyclopropanecarboxamide 
• 1242441-31-1 (1S,2S)-2-(4-{5-[(5-chloropyridin-2-yl)thio]-1-methyl-1H-imidazol-4-yl}phenyl)-N-(2-fluoroethyl)cyclopropanecarboxamide 

Relevant articles and documents

Discovery of MK-3168: A PET tracer for imaging brain fatty acid amide hydrolase

We report herein the discovery of a fatty acid amide hydrolase (FAAH) positron emission tomography (PET) tracer. Starting from a pyrazole lead, medicinal chemistry efforts directed toward reducing lipophilicity led to the synthesis of a series of imidazole analogues. Compound 6 was chosen for further profiling due to its appropriate physical chemical properties and excellent FAAH inhibition potency across species. [11C]-6 (MK-3168) exhibited good brain uptake and FAAH-specific signal in rhesus monkeys and is a suitable PET tracer for imaging FAAH in the brain.