1242654-02-9

Basic information

• Product Name: C₄₆H₄₇NO₆S
• CAS NO: 1242654-02-9
• Molecular Weight: 741.948
• Mol File: 1242654-02-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₄₆H₄₇NO₆S(CAS DataBase Reference)
• NIST Chemistry Reference: C₄₆H₄₇NO₆S(1242654-02-9)
• EPA Substance Registry System: C₄₆H₄₇NO₆S(1242654-02-9)

Safety Data

• Hazardous Substances Data: 1242654-02-9(Hazardous Substances Data)

Upstream product

• 1242654-00-7 2-((3R,4S,5R,6R)-3,4,5-tris(benzyloxy)-6-(benzyloxymethyl)-tetrahydro-2H-pyran-2-yl)thiazole-4-carbaldehyde 
• 22873-28-5 p-ethylphenylmagnesium bromide 

Relevant articles and documents

Synthesis of pyridazine and thiazole analogs as SGLT2 inhibitors

With anticipation of the improvement in biological aspects in our SGLT2 program, novel pyridazinyl and thiazolyl analogs were designed and efficiently synthesized. The installation of the pyridazine ring at the anomeric carbon of d-glucopyranose was carried out in a stereoselective fashion. On the other hand, a series of thiazolyl analogs was also synthesized through a coupling reaction between perbenzyl gluconolactone 9 and 2-lithiothiazole. Biological activities of the compounds thus prepared were evaluated by the in vitro SGLT2 inhibition assay. Considering assay results, the novel benzylpyridazinyl and benzylthiazolyl analogs, disclosed in this article, could be a quick reference to prospective SGLT2 inhibitors useful for pharmacotherapy.