124292-93-9

Basic information

• Product Name: 5(2H)-Oxazolone, 4-(1-methylethoxy)-2-phenyl-2-(trifluoromethyl)-
• CAS NO: 124292-93-9
• Molecular Formula: C13H12F3NO3
• Molecular Weight: 287.238
• Mol File: 124292-93-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5(2H)-Oxazolone, 4-(1-methylethoxy)-2-phenyl-2-(trifluoromethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 5(2H)-Oxazolone, 4-(1-methylethoxy)-2-phenyl-2-(trifluoromethyl)-(124292-93-9)
• EPA Substance Registry System: 5(2H)-Oxazolone, 4-(1-methylethoxy)-2-phenyl-2-(trifluoromethyl)-(124292-93-9)

Safety Data

• Hazardous Substances Data: 124292-93-9(Hazardous Substances Data)

Upstream product

• 434-45-7 2,2,2-Trifluoroacetophenone 
• 124292-87-1 ethyl 1-imino-2-isopropyloxy acetate 

Downstream Products

• 80232-86-6 2-phenyl-4,5,6,7-tetrahydrobenzo[d]thiazole 

Relevant articles and documents

Synthesis of 4-Alkoxy-1,3-oxazol-5(2H)-ones, Precursors of 1-Alkoxy-Substituted Nitrile Ylides

4-Alkoxy-1,3-oxazol-5(2H)-ones of type 4 and 7 were synthesized by two different methods: oxidation of the 4-(phenylthio)-1,3-oxazol-5(2H)-one 2a with m-chloroperbenzoic acid in the presence of an alcohol gave the corresponding 4-alkoxy derivatives 4, presumably via nucleophilic substitution of an intermediate sulfoxide (Scheme 2).The second approach is the BF3-catalyzed condensation of imino-acetates of type 6 and ketones (Scheme 3).The yields of this more straightforward method were modest due to the competitive formation of 1,3,5-triazine tricarboxylate 8.At 155 deg C, 1,3-oxazol-5(2H)-one 7b underwent decarboxylation leading to an alkoxy-substituted nitrile ylide which was trapped in a 1,3-dipolar cycloaddition by trifluoro-acetophenone to give the dihydro-oxazoles cis- and trans-9 (Scheme 4).In the absence of a dipolarophile, 1,5-dipolar cyclization of the intermediate nitrile ylide yielded isoindole derivatives 10 (Schemes 4 and 5).