1243166-48-4

Basic information

• Product Name: (1S)-1-(naphthalen-1-yl)ethanamine (R)-mandelate
• Synonyms: (1S)-1-(naphthalen-1-yl)ethanamine (R)-mandelate
• CAS NO: 1243166-48-4
• Molecular Weight: 323.392
• Mol File: 1243166-48-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (1S)-1-(naphthalen-1-yl)ethanamine (R)-mandelate(CAS DataBase Reference)
• NIST Chemistry Reference: (1S)-1-(naphthalen-1-yl)ethanamine (R)-mandelate(1243166-48-4)
• EPA Substance Registry System: (1S)-1-(naphthalen-1-yl)ethanamine (R)-mandelate(1243166-48-4)

Safety Data

• Hazardous Substances Data: 1243166-48-4(Hazardous Substances Data)

Upstream product

• 42882-31-5 (RS)-1-(1-naphthyl)ethylamine 
• 611-71-2 (R)-Mandelic Acid 
• 941-98-0 1'-naphthacetophenone 
• 1956-40-7 1-(1-naphthalenyl)ethanone oxime 

Downstream Products

• 10420-89-0 (S)-1-(1-Naphthyl)ethylamine 
• 3886-70-2 (R)-1-(1-Naphthyl)ethylamine 

Relevant articles and documents

Efficient synthesis and practical resolution of 1-(naphthalen-1-yl) ethanamine, a key intermediate for cinacalcet

An efficient synthesis of 1-(naphthalen-1-yl)ethanamine (RS-2) and its practical resolution to optically pure (1R)-(naphthalen-1-yl)ethanamine (R-(+)-2), a key intermediate in the synthesis of cinacalcet hydrochloride (1), is described. The resolution of RS-2 using R-(-)-mandelic acid as a resolving agent in ethanol was established on an industrial scale to give pure R-(+)-2 with >99.8% ee after liberation of the amine from its mandelate salt. An efficient process for the racemization of undesired isomer S-(-)-2 is also provided to maximize the yield of desired enantiomer.