124318-82-7

Basic information

• Product Name: (S)-1-{[2-O-4,4'-dimethoxytrityl-1-(hydroxymethyl)ethoxy]methyl}thymine
• Synonyms: (S)-1-{[2-O-4,4'-dimethoxytrityl-1-(hydroxymethyl)ethoxy]methyl}thymine
• CAS NO: 124318-82-7
• Molecular Weight: 532.593
• Mol File: 124318-82-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (S)-1-{[2-O-4,4'-dimethoxytrityl-1-(hydroxymethyl)ethoxy]methyl}thymine(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-1-{[2-O-4,4'-dimethoxytrityl-1-(hydroxymethyl)ethoxy]methyl}thymine(124318-82-7)
• EPA Substance Registry System: (S)-1-{[2-O-4,4'-dimethoxytrityl-1-(hydroxymethyl)ethoxy]methyl}thymine(124318-82-7)

Safety Data

• Hazardous Substances Data: 124318-82-7(Hazardous Substances Data)

Upstream product

• 7288-28-0 2,4-bis(trimethylsiloxy)-5-methylpyrimidine 
• 201732-39-0 (R)-1-{[2-O-t-butyldiphenylsilyl-1-(benzyloxymethyl)ethoxy]methyl}thymine 
• 201732-40-3 (R)-1-{[2-O-t-butyldiphenylsilyl-1-(hydroxymethyl)ethoxy]methyl}thymine 
• 65-71-4 thymin 
• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 50-00-0 formaldehyd 
• 124318-76-9 2,2-Dimethyl-propionic acid (R)-3-benzyloxy-2-hydroxy-propyl ester 

Downstream Products

• 124318-84-9 (R)-1-{[2-O-(2-cyanoethoxy)-diisopropylaminophosphino-1-O-(4,4'-dimethoxytritylmethyl)ethoxy]methyl}thymine 

Relevant articles and documents

A cytosine analogue containing a conformationally flexible acyclic linker for triplex formation at sites with contiguous G-C base pairs

Two nucleoside derivatives of the pyrimidine bases T and m(5ox)C have been prepared with flexible acyclic carbohydrate linkers. A new procedure, beginning with (R)-(-)-2,2-dimethyl-1,3-dioxolane-4-methanol permits the preparation of the stereochemically pure acyclic derivatives of both protected nucleoside analogues without contamination by a problematic rearrangement product. By simply increasing the flexibility of the carbohydrate portion of the am(5ox)C nucleoside derivative. 15-mer triplexes containing five contiguous G-C base pairs exhibit a 7-8 °C increase in T(m) value.