124341-37-3 Usage
Description
Benzoic acid, 3-(methylamino)-2-nitro(9CI) is an organic compound derived from benzoic acid with a methylamino group at the 3-position and a nitro group at the 2-position. It is a key intermediate in the synthesis of various pharmaceuticals and exhibits significant biological activities.
Uses
Used in Pharmaceutical Industry:
Benzoic acid, 3-(methylamino)-2-nitro(9CI) is used as an intermediate in the synthesis of Endophenazine B (E555485), a novel phenazine antibiotic. This antibiotic demonstrates potent antimicrobial activities against Gram-positive bacteria and some filamentous fungi, making it a valuable compound in the development of new antibiotics to combat drug-resistant infections.
Additionally, Benzoic acid, 3-(methylamino)-2-nitro(9CI) exhibits herbicidal activity against Lemna minor (duckweed), a problematic aquatic weed that can cause significant ecological and agricultural issues. Its use in the development of herbicides can help control the growth of such invasive species, thereby contributing to more sustainable agricultural practices and environmental management.
Check Digit Verification of cas no
The CAS Registry Mumber 124341-37-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,4,3,4 and 1 respectively; the second part has 2 digits, 3 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 124341-37:
(8*1)+(7*2)+(6*4)+(5*3)+(4*4)+(3*1)+(2*3)+(1*7)=93
93 % 10 = 3
So 124341-37-3 is a valid CAS Registry Number.
124341-37-3Relevant articles and documents
Cyclosporin derivatives
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Page/Page column 84, (2016/10/17)
The present invention relates to novel cyclosporin derivatives that do not cross the cellular membrane. The compounds according to the invention are used in medicine, more particularly in the treatment/diagnosis of acute and chronic inflammatory diseases,
Potential Antitumor Agents. 59. Structure-Activity Relationships for 2-Phenylbenzimidazole-4-carboxamides, a New Class of "Minimal" DNA-Intercalating Agents Which May Not Act via Topoisomerase II
Denny, William A.,Rewcastle, Gordon W.,Baguley, Bruce C.
, p. 814 - 819 (2007/10/02)
A series of substituted 2-phenylbenzimidazole-4-carboxamides has been synthesized and evaluated for in vitro and in vivo antitumor activity.These compounds represent the logical conclusion to our search for "minimal" DNA-intercalating agents with the lowest possible DNA-binding constants.Such "2-1" tricyclic chromophores, of lower aromaticity than the structurally similar 2-phenylquinolines, have the lowest DNA binding affinity yet seen in the broad series of tricyclic carboxamide intercalating agents.Despite very low in vitro cytotoxicities, several of the compoundshad moderate levels of in vivo antileukemic effects.However, the most interesting aspect of their biological activity was the lack of cross-resistance shown to an amsacrine-resistant P388 cell line, suggesting that these compounds may not express their cytotoxicity via interaction with topoisomerase II.
