124358-24-3

Basic information

• Product Name: 2-METHYL-5-NITROBENZOIC ACID ETHYL ESTER
• Synonyms: 2-METHYL-5-NITROBENZOIC ACID ETHYL ESTER;ethyl 2-Methyl-5-nitrobenzoate
• CAS NO: 124358-24-3
• Molecular Formula: C₁₀H₁₁NO₄
• Molecular Weight: 209.2
• Mol File: 124358-24-3.mol
• Article Data: 7

Chemical Properties

• Melting Point: 30-31 °C
• Boiling Point: 319.3°C at 760 mmHg
• Flash Point: 142.1°C
• Appearance: /
• Density: 1.216g/cm³
• Vapor Pressure: 0.000342mmHg at 25°C
• Refractive Index: 1.54
• CAS DataBase Reference: 2-METHYL-5-NITROBENZOIC ACID ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 2-METHYL-5-NITROBENZOIC ACID ETHYL ESTER(124358-24-3)
• EPA Substance Registry System: 2-METHYL-5-NITROBENZOIC ACID ETHYL ESTER(124358-24-3)

Safety Data

• Hazardous Substances Data: 124358-24-3(Hazardous Substances Data)

Usage

InChI:InChI=1/C10H11NO4/c1-3-15-10(12)9-6-8(11(13)14)5-4-7(9)2/h4-6H,3H2,1-2H3

Upstream product

• 64-17-5 ethanol 
• 1975-52-6 5-nitro-o-toluic acid 

Downstream Products

• 7335-32-2 ethyl 5-amino-2-methylbenzoate 
• 1606169-01-0 ethyl (5-{[6-(3-aminophenyl)pyrimidin-4-yl]amino}-2-methylbenzyl)ethylphosphinate 
• 1606169-00-9 ethyl ethyl(2-methyl-5-{[6-(3-nitrophenyl)pyrimidin-4-yl]amino}benzyl)phosphinate 
• 1606168-99-3 ethyl ethyl(5-{[6-(2-methoxyphenyl)pyrimidin-4-yl]amino}-2-methylbenzyl)phosphinate 
• 1606168-83-5 ethyl (5-amino-2-methylbenzyl)ethylphosphinate 
• 1606168-71-1 diethyl (5-{[6-(2-methoxyphenyl)pyrimidin-4-yl]amino}-2-methylbenzyl)phosphonate 
• 22474-47-1 (2-methyl-5-nitro-7-phenyl)methanol 
• 98799-27-0 2-(bromomethyl)-1-methyl-4-nitro-benzene 
• 1606168-49-3 diethyl (5-amino-2-methylbenzyl)phosphonate 
• 1606169-58-7 ethyl ethyl(2-methyl-5-nitrobenzyl)phosphinate 
• 1606169-48-5 diethyl (2-methyl-5-nitrobenzyl)phosphonate 
• 1351237-97-2 5-(3-(2-cyanopropan-2-yl)benzamido)-2-methyl-N-(thieno[2,3-b]pyrazin-6-yl)benzamide 
• 1351238-76-0 ethyl 5-(3-(2-cyanopropan-2-yl)benzamido)-2-methylbenzoate 
• 896160-38-6 5-(3-(2-cyanopropan-2-yl)benzamido)-2-methylbenzoic acid 

Relevant articles and documents

Synthesis and evaluation of phosphorus containing, specific CDK9/CycT1 inhibitors

Although there is a significant effort in the design of a selective CDK9/CycT1 inhibitor, no compound has been proven to be a specific inhibitor of this kinase so far. The aim of this research was to develop novel and selective phosphorus containing CDK9/CycT1 inhibitors. Molecules bearing phosphonamidate, phosphonate, and phosphinate moieties were synthesized. Prepared compounds were evaluated in an enzymatic CDK9/CycT1 assay. The most potent molecules were tested in cell-based toxicity and HIV proliferation assays. Selectivity of shortlisted compounds against CDKs and other kinases was tested. The best compound was shown to be a highly specific, ATP-competitive inhibitor of CDK9/CycT1 with antiviral activity.

THIENO (2, 3B) PYRAZINE COMPOUNDS AS B - RAF INHIBITORS

The invention relates to compounds according to general Formula (I) or a pharmaceutically acceptable salt thereof. The compounds can be used for the treatment of cancer.

ISOINDOLINE COMPOUNDS FOR THE TREATMENT OF SPINAL MUSCULAR ATROPHY AND OTHER USES

Disclosed is a compound of Formula (I) in which W and R1-R6 are defined herein. Also disclosed is a method of treating spinal muscular atrophy, as well as methods of using such compounds to increase SMN expression, increase EAAT2 expression, or increase the expression of a nucleic acid that encodes a translational stop codon introduced directly or indirectly by mutation or frameshift.