124388-97-2

Basic information

• Product Name: Nonanal, 9-bromo-
• CAS NO: 124388-97-2
• Molecular Formula: C9H17BrO
• Molecular Weight: 221.137
• Mol File: 124388-97-2.mol
• Article Data: 25

Chemical Properties

• CAS DataBase Reference: Nonanal, 9-bromo-(CAS DataBase Reference)
• NIST Chemistry Reference: Nonanal, 9-bromo-(124388-97-2)
• EPA Substance Registry System: Nonanal, 9-bromo-(124388-97-2)

Safety Data

• Hazardous Substances Data: 124388-97-2(Hazardous Substances Data)

Upstream product

• 55362-80-6 9-bromononan-1-ol 

Downstream Products

• 876143-55-4 5-[(R)-2-[benzyl-(9-bromononyl)amino]-1-(tert-butyldimethylsilanyloxy)ethyl]-8-benzyloxy-1H-quinolin-2-one 
• 29541-97-7 9-acetoxynonal 
• 1415971-17-3 (1-(10-oxodecyl)piperidin-4-yl)methyl 2-cyclohexyl-2-hydroxy-2-phenylacetate 
• 1415971-16-2 (1-(9-(1,3-dioxolan-2-yl)nonyl)piperidin-4-yl)methyl 2-cyclohexyl-2-hydroxy-2-phenylacetate 
• 1415970-74-9 (1-(9-((2R)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethylamino)nonyl)piperidin-4-yl)methyl 2-cyclohexyl-2-hydroxy-2-phenylacetate 
• 1416069-25-4 (3-(8-(1,3-dioxolan-2-yl)octyloxy)phenyl)(thiophen-2-yl)methanol 
• 1416069-24-3 3-(8-(1,3-dioxolan-2-yl)octyloxy)benzaldehyde 
• 1416065-91-2 (R)-quinuclidin-3-yl (3-(9-((R)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethylamino)nonyloxy)phenyl)-(phenyl)methylcarbamate 
• 1416069-23-2 (R)-quinuclidin-3-yl (3-(9-oxononyloxy)phenyl)(phenyl)-methylcarbamate 
• 1416069-22-1 (R)-quinuclidin-3-yl (3-(8-(1,3-dioxolan-2-yl)octyloxy)phenyl)(phenyl)methylcarbamate 
• 1416069-21-0 (3-(8-(1,3-dioxolan-2-yl)octyloxy)phenyl)(phenyl)methanamine 
• 1416069-20-9 2-(8-(3-(azido(phenyl)methyl)phenoxy)octyl)-1,3-dioxolane 
• 1416069-19-6 (3-(8-(1,3-dioxolan-2-yl)octyloxy)phenyl)(phenyl)methanol 
• 1416069-18-5 (3-(8-(1,3-dioxolan-2-yl)octyloxy)phenyl)(phenyl)methanone 

Relevant articles and documents

Nickel-Catalyzed Alkyl-Alkyl Cross-Couplings of Fluorinated Secondary Electrophiles: A General Approach to the Synthesis of Compounds having a Perfluoroalkyl Substituent

Fluorinated organic molecules are of interest in fields ranging from medicinal chemistry to polymer science. Described herein is a mild, convenient, and versatile method for the synthesis of compounds bearing a perfluoroalkyl group attached to a tertiary carbon atom by using an alkyl-alkyl cross-coupling. A nickel catalyst derived from NiCl2 glyme and a pybox ligand achieves the coupling of a wide range of fluorinated alkyl halides with alkylzinc reagents at room temperature. A broad array of functional groups is compatible with the reaction conditions, and highly selective couplings can be achieved on the basis of differing levels of fluorination. A mechanistic investigation has established that the presence of 2,2,6,6-tetramethyl-1-piperidinyloxy (TEMPO) inhibits cross-coupling under these conditions and that a TEMPO-electrophile adduct can be isolated.

Design, synthesis of symmetrical bivalent mimetics of annonaceous acetogenins and their cytotoxicities

A new series of linear dimeric compounds mimicking naturally occurring annonaceous acetogenins have been synthesized by bivalent analogue design, and their cytotoxicities have been evaluated against the growth of cancer cells by MTT method. Most of these compounds show selective action favored to human cancer cell lines over normal cell lines, and compound 9 with bis-terminal benzoquinone functionality exhibits an IC50 = 0.40 μM against MCF7 cell lines. This work mentions that appropriate conformational constraints might be a useful optimizing tool for this unique class of anticancer compounds.

Method for synthesizing (9Z, 12E)-9,12-tetradecadien-1-ol acetate

The invention belongs to the technical field of green pesticide synthesis, and discloses a novel method for synthesizing (9Z, 12E)-9,12-tetradecadien-1-ol acetate. According to the method, malonic acid and 9-bromo-1-nonyl alcohol are used as two starting raw materials. The method comprises the following steps: carrying out a Knoevenagel condensation reaction on malonic acid and propionaldehyde inthe presence of piperidine acetate to generate (E)-3-pentenoic acid, then carrying out lithium aluminum hydride reduction to obtain (E)-3-penten-1-ol, carrying out bromination reaction, and refluxingwith triphenylphosphine in acetonitrile to obtain (E)-3-pentenyltriphenylphosphine bromide; carrying out a PCC oxidation reaction on 9-bromo-1-nonanol to obtain 9-bromononanal, and then reacting the 9-bromononanal with potassium acetate to obtain 9-acetoxynonanal; and finally, carrying out a Wittig reaction on (E)-3-pentenyltriphenylphosphine bromide and 9-acetoxynonanal so as to obtain (9Z, 12E)-9,12-tetradecadien-1-ol acetate. An E-type double bond is constructed by utilizing the Knoevenagel condensation reaction of malonic acid and propionaldehyde, and the method has the advantages of mildreaction conditions, environmental friendliness, simple synthetic route and the like.

BIODEGRADABLE LIPIDS FOR THE DELIVERY OF ACTIVE AGENTS

The present invention relates to a cationic lipid having one or more biodegradable groups located in a lipidic moiety (e.g., a hydrophobic chain) of the cationic lipid. These cationic lipids may be incorporated into a lipid particle for delivering an active agent, such as a nucleic acid. The invention also relates to lipid particles comprising a neutral lipid, a lipid capable of reducing aggregation, a cationic lipid of the present invention, and optionally, a sterol. The lipid particle may further include a therapeutic agent such as a nucleic acid.