124455-77-2

Basic information

• Product Name: 1,4,5,6-tetrahydro-Cyclopenta[b]pyrrole-2-carboxylic acid ethyl ester
• Synonyms: 1,4,5,6-tetrahydro-Cyclopenta[b]pyrrole-2-carboxylic acid ethyl ester
• CAS NO: 124455-77-2
• Molecular Formula: C₁₀H₁₃NO₂
• Molecular Weight: 179.21572
• Mol File: 124455-77-2.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1,4,5,6-tetrahydro-Cyclopenta[b]pyrrole-2-carboxylic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4,5,6-tetrahydro-Cyclopenta[b]pyrrole-2-carboxylic acid ethyl ester(124455-77-2)
• EPA Substance Registry System: 1,4,5,6-tetrahydro-Cyclopenta[b]pyrrole-2-carboxylic acid ethyl ester(124455-77-2)

Safety Data

• Hazardous Substances Data: 124455-77-2(Hazardous Substances Data)

Usage

Molecular Weight

181.23 g/mol

Structure

Cyclopentane ring fused with a pyrrole ring, carboxylic acid functional group, and an ethyl ester group

Functional Groups

Carboxylic acid, ester, and pyrrole

Appearance

Colorless to pale yellow solid or liquid

Solubility

Soluble in organic solvents like ethanol, methanol, and acetone

Stability

Stable under normal temperature and pressure, but sensitive to heat, light, and moisture

Reactivity

Can undergo reactions such as esterification, hydrolysis, and substitution due to the presence of functional groups

Synthesis

Prepared through the cyclization of appropriate precursors, such as the reaction between a 1,4-dicarbonyl compound and an α-amino acid ester

Applications

Used in organic synthesis and pharmaceutical research, potentially as a building block for the development of new drugs or complex molecules

Safety

Handle with care, as it may be harmful if swallowed, inhaled, or absorbed through the skin; avoid contact with eyes and wear appropriate protective gear

Storage

Store in a cool, dry, and well-ventilated area, away from heat, light, and sources of ignition

Regulatory Status

Not specifically regulated, but general safety precautions and guidelines for handling chemicals should be followed

Environmental Impact

Potentially harmful to aquatic life and should be disposed of according to local regulations and guidelines

Synonyms

Ethyl 2-oxo-1,4,5,6-tetrahydro-1H-cyclopenta[b]pyrrole-2-carboxylate, 1,4,5,6-Tetrahydrocyclopenta[b]pyrrole-2-carboxylic acid ethyl ester

Upstream product

• 120-92-3 cyclopentanone 
• 936-52-7 1-(N-morpholino)cyclopent-1-ene 
• 73472-94-3 ethyl 3-bromo-2-(hydroxyimino)propanoate 
• 124455-65-8 ethyl 3-(2-azidocyclopent-1-enyl)-3-hydroxypropionate 
• 119476-42-5 2-Azido-1-cyclopentene-1-carboxaldehyde 
• 2611-03-2 2-chlorocyclopent-1-ene-1-carbaldehyde 
• 124455-68-1 ethyl 3-(2-azidocyclopent-2-enylidene)-propionate 

Downstream Products

• 1041429-47-3 4-oxo-1,4,5,6-tetrahydrocyclopenta[b]pyrrole-2-carboxylic acid 
• 1041430-83-4 ethyl 6-oxo-1,4,5,6-tetrahydrocyclopenta[b]pyrrole-2-carboxylate 
• 1142816-48-5 C₁₀H₁₁NO₃ 
• 1041429-45-1 1,4,5,6-tetrahydrocyclopenta[b]pyrrole-2-carboxylic acid 
• 685142-02-3 3-phenyl-2(RS)-{2-[(1,4,5,6-tetrahydro-cyclopenta[b]pyrrole-2-carbonyl)-amino]-benzoylamino}-propionic acid ethyl ester 

Relevant articles and documents

An improved route to cycloalka[b]pyrrole 2-carboxylates

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PHARMACEUTICAL COMPOSITION CONTAINING FUSED HETERO-RING DERIVATIVE

The present invention provides a compound which indicates a histamine H4 receptor modulating activity.A compound represented by a formula (I): wherein A ring is a ring represented by the following formula: wherein R1 is substituted or unsubstituted alkyl, etc., W is -O-, etc., n is an integer of 0 to 6; X is N(R7)- or -O-; R7 is hydrogen, substituted or unsubstituted alkyl, etc.; Y is-C(R8)= or -N=; R8 is hydrogen, substituted or unsubstituted alkyl, etc.; Z is =O, =S, etc.; B ring is a ring represented by the following formula wherein R10 is each independently substituted or unsubstituted alkyl, halogen, hydroxy, substituted or unsubstituted alkyloxy, substituted or unsubstituted amino; R11, R12a and R12b are each independently hydrogen or substituted or unsubstituted alkyl, etc.; p is an integer of 0 to 4, or its pharmaceutically acceptable salt, or a solvate thereof.The present invention provides a compound which indicates a histamine H4 receptor modulating activity. A compound represented by a formula (I): wherein A ring is a ring represented by the following formula: wherein R 1 is substituted or unsubstituted alkyl, etc., W is -O-, etc., n is an integer of 0 to 6; X is N(R 7 )- or -O-; R 7 is hydrogen, substituted or unsubstituted alkyl, etc.; Y is-C(R 8 )= or -N=; R 8 is hydrogen, substituted or unsubstituted alkyl, etc.; Z is =O, =S, etc.; B ring is a ring represented by the following formula wherein R 10 is each independently substituted or unsubstituted alkyl, halogen, hydroxy, substituted or unsubstituted alkyloxy, substituted or unsubstituted amino; R 11 , R 12a and R 12b are each independently hydrogen or substituted or unsubstituted alkyl, etc.; p is an integer of 0 to 4, or its pharmaceutically acceptable salt, or a solvate thereof.

New Cyclopenta-pyrroles and -pyridines by Reaction of 2-Azido- and 2-Phosphoranylideneaminocyclopent-1-ene-1-carbaldehydes with Aliphatic Esters

A new cyclopentapyrrole has been synthesized by reaction of 2-azidocyclopent-1-ene-1-carbaldehyde with ethyl acetate and subsequent thermal cyclisation.Dicyclopentapyrazines have been isolated from a similar reaction with ethyl propionate or t-but