124467-36-3

Basic information

• Product Name: 2-CHLORO-7,8-DIHYDRO-6H-QUINOLIN-5-ONE
• Synonyms: 2-CHLORO-7,8-DIHYDRO-6H-QUINOLIN-5-ONE;2-chloro-5,6,7,8-tetrahydroquinolin-5-one
• CAS NO: 124467-36-3
• Molecular Formula: C₉H₈ClNO
• Molecular Weight: 181.62
• Mol File: 124467-36-3.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 325.5 °C at 760 mmHg
• Flash Point: 150.6 °C
• Appearance: /
• Density: 1.316 g/cm³
• Vapor Pressure: 0.00023mmHg at 25°C
• Refractive Index: 1.583
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: -1.44±0.20(Predicted)
• CAS DataBase Reference: 2-CHLORO-7,8-DIHYDRO-6H-QUINOLIN-5-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-7,8-DIHYDRO-6H-QUINOLIN-5-ONE(124467-36-3)
• EPA Substance Registry System: 2-CHLORO-7,8-DIHYDRO-6H-QUINOLIN-5-ONE(124467-36-3)

Safety Data

• Hazardous Substances Data: 124467-36-3(Hazardous Substances Data)

Usage

General Description

2-Chloro-7,8-dihydro-6H-quinolin-5-one is a chemical compound that is a derivate of quinolinone, a class of organic compounds commonly used in medicinal and pharmaceutical chemistry due to their ability to display a wide range of biological activities. The presence of a chlorine atom at its second position makes it a potential intermediate for the synthesis of more complex compounds. Its structure involves the combination of a benzene ring and a pyridine ring forming a bicyclic system. While there's not much specific information about its properties or uses, being an organic chemical it usually is a potential candidate for studies in drug synthesis, chemical reactions, and pharmacology. As with all chemicals, careful handling under professional supervision is essential due to potential toxicity or reactivity issues.

InChI:InChI=1/C9H8ClNO/c10-9-5-4-6-7(11-9)2-1-3-8(6)12/h4-5H,1-3H2

Upstream product

• 15450-69-8 5,6,7,8-tetrahydro-5-oxo-2(1H)-quinolinone 
• 106551-76-2 1,2,5,6,7,8-Hexahydro-2,5-dioxo-3-quinolinecarboxylic acid 
• 504-02-9 1,3-cylohexanedione 
• 5220-49-5 3-amino-cyclohex-2-enone 

Downstream Products

• 864225-58-1 C₁₉H₂₁N₃O 
• 1241496-36-5 [(2S,4R)-2-cyclohexyl-4-phenylpiperidin-1-yl][(3R,4S)-2'-methyl-7',8'-dihydro-6'H-spiro[pyrrolidine-3,5'-quinolin]-4-yl]methanone 
• 1355612-02-0 C₂₂H₂₅ClN₂O₂ 
• 1429912-32-2 5-{[(1R,2S)-2-aminocyclohexyl]amino}-3-[(5-methyl-7,8-dihydroquinolin-2-yl)amino]pyridine-2-carboxamide 
• 1429914-15-7 tert-butyl (1S,2R)-2-(6-cyano-5-(5-hydroxy-5-methyl-5,6,7,8-tetrahydroquinolin-2-ylamino)pyridin-3-ylamino)cyclohexylcarbamate 
• 1429914-13-5 2-[(diphenylmethylidene)amino]-5-methyl-5,6,7,8-tetrahydroquinolin-5-ol 
• 1119227-47-2 2-(2,6-diethyl-phenyl)-7,8-dihydro-6H-quinolin-5-one 
• 864224-08-8 2-phenylethynyl-7,8-dihydro-6H-quinolin-5-one 

Relevant articles and documents

SHP2 INHIBITORS, COMPOSITIONS AND USES THEREOF

Provided are compounds of Formula (I), methods of using the compounds as SHP2 inhibitors, and pharmaceutical compositions comprising such compounds. The compounds are useful in treating SHP2-mediated diseases.

HETEROARYLCARBOXAMIDE DERIVATIVES AS PLASMA KALLIKREIN INHIBITORS

The present invention relates to compounds of general formula I, wherein D1 to D3, A, R1, R2, Y and n are defined as in claim 1, which have valuable pharmacological properties, in particular are inhibitors of pl

Novel 5-aminotetrahydroquinoline-2-carboxylic acids and their use

The present application relates to novel 5-amino-5,6,7,8-tetrahydroquinoline-2-carboxylic acids, to processes for their preparation, to their use for the treatment and/or prevention of diseases, and to their use for producing medicaments for the treatment and/or prevention of diseases, especially for the treatment and/or prevention of cardiovascular and cardiopulmonary disorders.