124478-60-0

Basic information

• Product Name: Aglepristone
• Synonyms: AGLEPRISTONE;Estra-4,9-dien-3-one, 11-4-(dimethylamino)phenyl-17-hydroxy-17-(1Z)-1-propenyl-, (11.beta.,17.beta.)-;(8S,11R,13S,14S,17S)-11-(4-Dimethylaminophenyl)-17-hydroxy-13-methyl-17-[(Z)-prop-1-enyl]-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one
• CAS NO: 124478-60-0
• Molecular Formula: C29H37NO2
• Molecular Weight: 431.616
• Product Categories: Steroid and Hormone
• Mol File: 124478-60-0.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 613.555 °C at 760 mmHg
• Flash Point: 324.866 °C
• Appearance: /
• Density: 1.16 /cm³
• Vapor Pressure: 6.55E-16mmHg at 25°C
• Refractive Index: 1.613
• Storage Temp.: Amber Vial, Refrigerator, Under inert atmosphere
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• CAS DataBase Reference: Aglepristone(CAS DataBase Reference)
• NIST Chemistry Reference: Aglepristone(124478-60-0)
• EPA Substance Registry System: Aglepristone(124478-60-0)

Safety Data

• Hazardous Substances Data: 124478-60-0(Hazardous Substances Data)

Usage

Description

Aglepristone, also known as RU-486, is a synthetic steroidal compound derived from 19-nor-deoxycorticosterone. It functions as a potent anti-progestogen and glucocorticoid, with the ability to bind to progesterone receptors and block their activity. This unique property makes it a versatile pharmaceutical agent for various applications.

Uses

Used in Veterinary Medicine:
Aglepristone is used as a treatment to induce parturition in ewes and their newborns, facilitating easier and safer birthing processes for both the mother and the offspring.
Used in Human Medicine:
Aglepristone is used as a competitive progesterone antagonist for the treatment of various progesterone-dependent physiological and pathological conditions. It is an effective means of terminating pregnancy in most species, offering a non-surgical alternative for pregnancy termination.
Used in Contraception:
Aglepristone is used as a contraceptive agent, preventing sperm progression toward the oviducts and fertilization in inseminated females, thus providing a method for birth control and family planning.

Veterinary Drugs and Treatments

Aglepristone is labeled (in the U.K. and elsewhere) for pregnancy termination in bitches up to 45 days after mating. In dogs, aglepristone may prove useful in inducing parturition or treating pyometra complex (often in combination with a prostaglandin F analog such as cloprostenol). In cats, it may be of benefit for pregnancy termination (one study documented 87% efficacy when administered at the recommended dog dose at day 25) or in treating mammary hyperplasias or pyometras.

InChI:InChI=1/C29H37NO2/c1-5-15-29(32)16-14-26-24-12-8-20-17-22(31)11-13-23(20)27(24)25(18-28(26,29)2)19-6-9-21(10-7-19)30(3)4/h5-7,9-10,15,17,24-26,32H,8,11-14,16,18H2,1-4H3/b15-5-/t24-,25+,26-,28-,29+/m0/s1