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1245215-48-8

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1245215-48-8 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1245215-48-8 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,4,5,2,1 and 5 respectively; the second part has 2 digits, 4 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 1245215-48:
(9*1)+(8*2)+(7*4)+(6*5)+(5*2)+(4*1)+(3*5)+(2*4)+(1*8)=128
128 % 10 = 8
So 1245215-48-8 is a valid CAS Registry Number.

1245215-48-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name methyl 4-hydroxy-2-methyl-2H-indazole-6-carboxylate

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1245215-48-8 SDS

1245215-48-8Relevant articles and documents

The design and synthesis of indazole and pyrazolopyridine based glucokinase activators for the treatment of Type 2 diabetes mellitus

Pfefferkorn, Jeffrey A.,Tu, Meihua,Filipski, Kevin J.,Guzman-Perez, Angel,Bian, Jianwei,Aspnes, Gary E.,Sammons, Matthew F.,Song, Wei,Li, Jian-Cheng,Jones, Christopher S.,Patel, Leena,Rasmusson, Tim,Zeng, Dongxiang,Karki, Kapil,Hamilton, Michael,Hank, Richard,Atkinson, Karen,Litchfield, John,Aiello, Robert,Baker, Levenia,Barucci, Nicole,Bourassa, Patricia,Bourbounais, Francis,D'Aquila, Theresa,Derksen, David R.,MacDougall, Margit,Robertson, Alan

, p. 7100 - 7105 (2013/01/15)

Glucokinase activators represent a promising potential treatment for patients with Type 2 diabetes. Herein, we report the identification and optimization of a series of novel indazole and pyrazolopyridine based activators leading to the identification of 4-(6-(azetidine-1-carbonyl)-5-fluoropyridin-3- yloxy)-2-ethyl-N-(5-methylpyrazin-2-yl)-2H-indazole-6-carboxamide (42) as a potent activator with favorable preclinical pharmacokinetic properties and in vivo efficacy.

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