1245282-59-0

Basic information

• Product Name: (E)-N-(3-(3-(4-fluorophenyl)acryloyl)-4-hydroxyphenyl)acetamide
• Synonyms: (E)-N-(3-(3-(4-fluorophenyl)acryloyl)-4-hydroxyphenyl)acetamide
• CAS NO: 1245282-59-0
• Molecular Weight: 299.301
• Mol File: 1245282-59-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (E)-N-(3-(3-(4-fluorophenyl)acryloyl)-4-hydroxyphenyl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-N-(3-(3-(4-fluorophenyl)acryloyl)-4-hydroxyphenyl)acetamide(1245282-59-0)
• EPA Substance Registry System: (E)-N-(3-(3-(4-fluorophenyl)acryloyl)-4-hydroxyphenyl)acetamide(1245282-59-0)

Safety Data

• Hazardous Substances Data: 1245282-59-0(Hazardous Substances Data)

Upstream product

• 103-90-2 4-acetaminophenol 
• 7298-67-1 5-acetamido-2-hydroxyacetophenone 
• 459-57-4 4-fluorobenzaldehyde 

Downstream Products

• 923138-98-1 N-(2-(4-fluorophenyl)-4-oxo-4H-chromen-6-yl)acetamide 
• 1245282-73-8 N-(2-(4-fluorophenyl)-3-hydroxy-4-oxo-4H-chromen-6-yl)acetamide 

Relevant articles and documents

COMPOUNDS FOR THE TREATMENT OF AMYLOID-ASSOCIATED DISEASES

This invention provides novel compounds of formulae (I) or (II) or a stereoisomer, enantiomer, racemic, or tautomer thereof, (I) (II) wherein the substituents are as defined in the specification. The present invention also relates to the novel compounds for use as a medicine, more in particular for the prevention or treatment of amyloid-related diseases, more specifically certain neurological disorders, such as disorders collectively known as tauopathies, disorders characterized by cytotoxic α-synuclein amyloidogenesis. The present invention also relates to the use of said novel compounds for the manufacture of medicaments useful for treating such amyloid-related diseases. The present invention further relates to pharmaceutical compositions including said novel compounds and to methods for the preparation of said novel compounds.

Anti-HIV and antiplasmodial activity of original flavonoid derivatives

In our search for potent anti-HIV and antiplasmodial agents, novel series of flavonoid derivatives and their chalcone intermediates were synthesized and evaluated for inhibition of HIV multiplication and antiproliferative activity on Plasmodium falciparum