124530-70-7

Basic information

• Product Name: 1H-Benzimidazole,2-[(1-methylethyl)thio]-(9CI)
• Synonyms: 1H-Benzimidazole,2-[(1-methylethyl)thio]-(9CI);2-(Isopropylthio)-1H-benzimidazole;2-(isopropylthio)-1H-benzo[d]imidazole
• CAS NO: 124530-70-7
• Molecular Formula: C₁₀H₁₂N₂S
• Molecular Weight: 192.28
• Product Categories: BENZIMIDAZOLE
• Mol File: 124530-70-7.mol
• Article Data: 2

Chemical Properties

• Melting Point: 187 °C
• Boiling Point: 347.0±25.0 °C(Predicted)
• Appearance: /
• Density: 1.19±0.1 g/cm3(Predicted)
• PKA: 10.80±0.10(Predicted)
• CAS DataBase Reference: 1H-Benzimidazole,2-[(1-methylethyl)thio]-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Benzimidazole,2-[(1-methylethyl)thio]-(9CI)(124530-70-7)
• EPA Substance Registry System: 1H-Benzimidazole,2-[(1-methylethyl)thio]-(9CI)(124530-70-7)

Safety Data

• Hazardous Substances Data: 124530-70-7(Hazardous Substances Data)

Usage

Also known as

1-methyl-1H-benzimidazole-2-thiol or 1-methyl-2-mercaptobenzimidazole

Structure

Benzimidazole derivative with a thioether functional group

Potential applications

Pharmaceutical and agrochemical industries

Biological activities

Unknown, but may have potential in the development of new drugs or crop protection products

Safety

Handle with caution and follow proper safety protocols in laboratory or industrial settings.

Upstream product

• 583-39-1 2,3-dihydrobenzimidazol-2-thione 
• 75-26-3 isopropyl bromide 
• 134469-07-1 Benzimidazol-2-thiol 

Downstream Products

• 634193-86-5 1-[(1-methylethyl)thio]-1-[(2,4,6-trimethylphenyl)methyl]benzimidazole 
• 634193-84-3 2-[(1-methylethyl)thio]-1-(phenylmethyl)benzimidazole 
• 634193-91-2 2-[(1-methylethyl)sulfonyl]-1-(phenylmethyl)benzimidazole 
• 634194-02-8 2-[(1-methylethenyl)sulfonyl]-1-(phenylmethyl)benzimidazole 
• 634193-99-0 1-methyl-2-{[1-methyl-1-(phenylseleno)ethyl]sulfonyl}benzimidazole 
• 634193-92-3 1-[(3,5-dimethylphenyl)methyl]-2-[(1-methylethyl)sulfonyl]benzimidazole 
• 634194-03-9 1-[(3,5-dimethylphenyl)methyl]-2-[(1-methylethenyl)sulfonyl]benzimidazole 
• 634193-93-4 1-[(1-methylethyl)sulfonyl]-1-[(2,4,6-trimethylphenyl)methyl]benzimidazole 
• 634193-98-9 2-{[1-methyl-2-(phenylseleno)ethyl]sulfonyl}-1-(phenylmethyl)benzimidazole 

Relevant articles and documents

Synthesis and preliminary evaluation of benzimidazole derivatives as antimicrobial agents

A series of 2-alkylsulphanylbenzimidazoles was synthesised and the compounds were evaluated for their in vitro antimicrobial activity. The structures of the compounds were confirmed by 1H-NMR and IR data, and their purity by elemental analysis. Antimycobacterial activities against Mycobacterium tuberculosis and non-tuberculous mycobacteria as well as antifungal activities against Candida albicans, Candida tropicalis, Candida krusei, Candida glabrata, Trichosporon beigelii, Trichophyton mentagrophytes and Aspergillus fumigatus were expressed as the corresponding MIC values. The substances exhibited appreciable antimycobacterial activity, in particular, against non-tuberculous mycobacteria. The activity of the most active compound in the set, 3,5-dinitro derivative 4t, exceeded that of the standard isoniazide against M. kansasii and M. avium. The antifungal activities of the compounds were relatively low. A weak antifungal effect was observed against the dermatophyte Trichophyton mentagrophytes. None of the compounds showed significant inhibitory activity against yeasts.