1245555-86-5

Basic information

• Product Name: N-(3-ethynylphenyl)-6-fluoropyrido[3,4-d]pyrimidin-4-amine
• Synonyms: N-(3-ethynylphenyl)-6-fluoropyrido[3,4-d]pyrimidin-4-amine
• CAS NO: 1245555-86-5
• Molecular Weight: 264.262
• Mol File: 1245555-86-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-(3-ethynylphenyl)-6-fluoropyrido[3,4-d]pyrimidin-4-amine(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3-ethynylphenyl)-6-fluoropyrido[3,4-d]pyrimidin-4-amine(1245555-86-5)
• EPA Substance Registry System: N-(3-ethynylphenyl)-6-fluoropyrido[3,4-d]pyrimidin-4-amine(1245555-86-5)

Safety Data

• Hazardous Substances Data: 1245555-86-5(Hazardous Substances Data)

Upstream product

• 54060-30-9 3-acetylenephenylamine 
• 175357-98-9 4-chloro-6-fluoro-pyrido[3,4-d]pyrimidine 

Relevant articles and documents

PRODRUG FORMS OF KINASE INHIBITORS AND THEIR USE IN THERAPY

The invention provides novel prodrug compounds comprising a kinase inhibitor and a reductively-activated fragmenting aromatic nitroheterocycle or aromatic nitrocarbocycle trigger, where the compound carries a positive charge. In preferred embodiments, the compounds are of Formula I: where: X is any negatively charged counterion; R1 is a group of the formula —(CH2)nTr, where Tr is an aromatic nitroheterocycle or aromatic nitrocarbocycle and —(CH2)nTr acts as a reductively-activated fragmenting trigger; and n is an integer from 0 to 6; R2, R3 and R4 may each independently be selected from aliphatic or aromatic groups of a tertiary amine kinase inhibitor (R2)(R3)(R4)N, or two of R2, R3, and R4 may form an aliphatic or aromatic heterocyclic amine ring of a kinase inhibitor, or one of R2, R3 and R4 may be absent and two of R2, R3 and R4 form an aromatic heterocyclic amine ring of a kinase inhibitor. The compounds of the invention are useful in treating proliferative diseases such as cancer.