1245645-97-9

Basic information

• Product Name: 4-Chloro-5-nitro-1H-pyrrolo[2,3-b]pyridine
• Synonyms: 4-Chloro-5-nitro-1H-pyrrolo[2,3-b]pyridine;1H-Pyrrolo[2,3-b]pyridine, 4-chloro-5-nitro-
• CAS NO: 1245645-97-9
• Molecular Formula: C₇H₄ClN₃O₂
• Molecular Weight: 197.57856
• Mol File: 1245645-97-9.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Density: 1.661±0.06 g/cm3(Predicted)
• PKA: 11.23±0.40(Predicted)
• CAS DataBase Reference: 4-Chloro-5-nitro-1H-pyrrolo[2,3-b]pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Chloro-5-nitro-1H-pyrrolo[2,3-b]pyridine(1245645-97-9)
• EPA Substance Registry System: 4-Chloro-5-nitro-1H-pyrrolo[2,3-b]pyridine(1245645-97-9)

Safety Data

• Hazardous Substances Data: 1245645-97-9(Hazardous Substances Data)

Usage

General Description

4-Chloro-5-nitro-1H-pyrrolo[2,3-b]pyridine is a chemical compound with the molecular formula C8H5ClN2O2. It is a nitro-substituted pyrrolopyridine derivative, and it has a chlorine atom at the 4-position and a nitro group at the 5-position of the pyrrolopyridine ring. 4-Chloro-5-nitro-1H-pyrrolo[2,3-b]pyridine is commonly used in the field of medicinal chemistry for the development of pharmaceutical drugs and agrochemicals. It is also used as an intermediate in the synthesis of various biologically active compounds. 4-Chloro-5-nitro-1H-pyrrolo[2,3-b]pyridine is known for its potential biological activities, including anti-cancer, anti-inflammatory, and anti-bacterial properties, making it a valuable compound for research and development purposes.

Upstream product

• 417721-69-8 4-chloro-3-iodopyridin-2-ylamine 
• 1310729-70-4 4-chloro-3-iodo-5-nitropyridin-2-amine 
• 1310729-72-6 4-chloro-3-ethynyl-5-nitropyridin-2-amine 
• 1310729-71-5 4-chloro-5-nitro-3-((trimethylsilyl)ethynyl)pyridin-2-amine 

Downstream Products

• 1310731-34-0 C₁₃H₁₈N₄ 
• 1310728-76-7 1-cyclohexyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine 
• 1310735-06-8 N-cyclohexyl-5-nitro-1-tosyl-1H-pyrrolo[2,3-b]pyridin-4-amine 
• 1310730-49-4 N⁴-cyclohexyl-1-tosyl-1H-pyrrolo[2,3-b]pyridine-4,5-diamine 
• 1421338-18-2 C₂₂H₂₆N₄O₃S 
• 1310730-50-7 N-(4-(cyclohexylamino)-1-tosyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-2,2,2-trifluoroacetamide 
• 1310732-75-2 1-cyclohexyl-2-methyl-6-tosyl- 1,6-dihydroimidazo[4,5- d]pyrrolo[2,3-b]pyridine 
• 1310732-76-3 1-cyclohexyl-6-tosyl-2- (trifluoromethyl)-1,6- dihydroimidazo[4,5-d]pyrrolo[2,3- b]pyridine 
• 1310722-03-2 1-cyclohexyl-2-methyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine 
• 1310722-04-3 1-cyclohexyl-2-(trifluoromethyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine 
• 1310731-33-9 C₁₃H₁₆N₄O₂ 
• 1421338-17-1 4-chloro-1-(4-methylbenzenesulfonyl)-5-nitro-1H-pyrrolo[2,3-b]pyridine 

Relevant articles and documents

Design and synthesis of tricyclic cores for kinase inhibition

Interest in therapeutic kinase inhibitors continues to grow beyond success in oncology. To date, ATP-mimetic kinase inhibitors have focused primarily on monocyclic and bicyclic heterocyclic cores. We sought to expand on the repertoire of potential cores for kinase inhibition by exploring tricyclic variants of classical bicyclic hinge binding motifs such as pyrrolopyridine and pyrrolopyrazine. Herein we describe the syntheses of eight alternative tricyclic cores as well as in vitro screening results for representative kinases of potential therapeutic interest.