124568-12-3

Basic information

• Product Name: (2S,R_S)-2-benzyloxy-3-fluoro-1-(p-tolylsulphinyl)propane
• Synonyms: (2S,R_S)-2-benzyloxy-3-fluoro-1-(p-tolylsulphinyl)propane
• CAS NO: 124568-12-3
• Molecular Weight: 306.401
• Mol File: 124568-12-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (2S,R_S)-2-benzyloxy-3-fluoro-1-(p-tolylsulphinyl)propane(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,R_S)-2-benzyloxy-3-fluoro-1-(p-tolylsulphinyl)propane(124568-12-3)
• EPA Substance Registry System: (2S,R_S)-2-benzyloxy-3-fluoro-1-(p-tolylsulphinyl)propane(124568-12-3)

Safety Data

• Hazardous Substances Data: 124568-12-3(Hazardous Substances Data)

Upstream product

• 105984-80-3 (+)-(R)-1-fluoro-3-<(4-methylphenyl)sulfinyl>-2-propanone 
• 100-39-0 benzyl bromide 
• 114107-02-7 (2S,R_S)-β-fluoromethyl-β-hydroxy sulfoxide 

Downstream Products

• 62222-04-2 2-(benzyloxy)acrylaldehyde 
• 124568-19-0 (2S)-2-benzyloxy-3-fluoropropanal 
• 242804-99-5 N-[(2R,Z)-3-fluoro-2-(phenylmethoxy)propylidene]-benzenemethanamine N-oxide 
• 124568-28-1 (R)-methyl O-benzyl-3-fluorolactate 
• 124568-24-7 (R)-2-benzyloxy-3-fluoropropanal dimethyl acetal 
• 145286-27-7 (R)-2-Benzyloxy-3-fluoro-propionaldehyde O-benzyl-oxime 
• 145286-28-8 (R)-2-Benzyloxy-3-fluoro-propionaldehyde O-benzyl-oxime 
• 145286-31-3 (R)-O-benzyl-N-(2-benzyloxy-3-fluoro)-1-propyl hydroxylamine 
• 145286-26-6 (E,R)-2-benzyloxy-3-fluoropropanal oxime 
• 145286-30-2 (R)-N-(2-benzyloxy-3-fluoro)-1-propyl hydroxylamine 
• 124588-26-7 (2S)-1-trifluoroacetyloxy-1-tolylthio-2-benzyloxy-3-fluoropropane 
• 124568-15-6 (1R,2S)-1-acetyloxy-2-benzyloxy-3-fluoro-1-(p-tolylthio)propane 
• 124568-16-7 (1S,2S)-1-acetyloxy-2-benzyloxy-3-fluoro-1-(p-tolylthio)propane 

Relevant articles and documents

Stereoselective synthesis of fluorinated isoxazolidines and 2,3- dihydroisoxazoles: A cycloadditive route to enantiomerically pure amino fluoro alcohols

3-(Fluoroalkyl)isoxazolidines 6 and -2,3-dihydroisoxazoles 8 have been obtained in enantiomerically pure form with good diastereoselectivity by 1,3- dipolar cycloaddition of diethyl fumarate and dimethylacetylene dicarboxylate, respectively, to the chiral fluorinated nitrone (R)-5. The latter has been prepared from the β-fluoromethyl-β-oxo sulfoxide (R(S)-1, by a synthetic sequence where the chiral and enantiomerically pure sulfinyl function acts as a removable source of chirality. Reductive opening of isoxazolidines 6 then afforded amino fluoromethyl diols 7 in good yields.