1245913-04-5

Basic information

• Product Name: trimethyl((4-phenoxyphenyl)ethynyl)silane
• Synonyms: trimethyl((4-phenoxyphenyl)ethynyl)silane
• CAS NO: 1245913-04-5
• Molecular Weight: 266.415
• Mol File: 1245913-04-5.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: trimethyl((4-phenoxyphenyl)ethynyl)silane(CAS DataBase Reference)
• NIST Chemistry Reference: trimethyl((4-phenoxyphenyl)ethynyl)silane(1245913-04-5)
• EPA Substance Registry System: trimethyl((4-phenoxyphenyl)ethynyl)silane(1245913-04-5)

Safety Data

• Hazardous Substances Data: 1245913-04-5(Hazardous Substances Data)

Upstream product

• 101-55-3 4-Bromodiphenyl ether 
• 1066-54-2 trimethylsilylacetylene 
• 4200-06-0 1-(4-ethynylphenoxy)benzene 
• 81290-20-2 (trifluoromethyl)trimethylsilane 

Downstream Products

• 4200-06-0 1-(4-ethynylphenoxy)benzene 
• 4200-17-3 1,4-bis(4-phenoxyphenyl)buta-1,3-diyne 

Relevant articles and documents

Iron-Catalyzed Tertiary Alkylation of Terminal Alkynes with 1,3-Diesters via a Functionalized Alkyl Radical

Direct oxidative C(sp)?H/C(sp3)?H cross-coupling offers an ideal and environmentally benign protocol for C(sp)?C(sp3) bond formations. As such, reactivity and site-selectivity with respect to C(sp3)?H bond cleavage have remained a persistent challenge. Herein is reported a simple method for iron-catalyzed/silver-mediated tertiary alkylation of terminal alkynes with readily available and versatile 1,3-dicarbonyl compounds. The reaction is suitable for an array of substrates and proceeds in a highly selective manner even employing alkanes containing other tertiary, benzylic, and C(sp3)?H bonds alpha to heteroatoms. Elaboration of the products enables the synthesis of a series of versatile building blocks. Control experiments implicate the in situ generation of a tertiary carbon-centered radical species.

BTK INHIBITOR

Provided are a series of BTK inhibitors, and specifically disclosed are a compound, pharmaceutically acceptable salt thereof, tautomer thereof or prodrug thereof represented by formula (I), (II), (III) or (IV).

NHC catalysed trimethylsilylation of terminal alkynes and indoles with Ruppert's reagent under solvent free conditions

An organo-catalytic protocol for the trimethylsilylation of terminal alkynes employing Ruppert's reagent (CF3SiMe3) as a trimethylsilyl source has been developed under solvent and fluoride free conditions. This method was found to be very effective as a variety of terminal alkynes bearing aliphatic or aromatic substituents underwent smooth transformation to their corresponding silylated products in excellent yields within a few minutes using N-heterocyclic carbene as an organo-catalyst. This methodology was also applied to the chemospecific N-silylation of indoles. This journal is