1246200-01-0

Basic information

• Product Name: 6-(2-bromophenyl)-8-methyl-2-(methylthio)pyrido[2,3-d]-pyrimidin-7(8H)-one
• Synonyms: 6-(2-bromophenyl)-8-methyl-2-(methylthio)pyrido[2,3-d]-pyrimidin-7(8H)-one
• CAS NO: 1246200-01-0
• Molecular Weight: 362.25
• Mol File: 1246200-01-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 6-(2-bromophenyl)-8-methyl-2-(methylthio)pyrido[2,3-d]-pyrimidin-7(8H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 6-(2-bromophenyl)-8-methyl-2-(methylthio)pyrido[2,3-d]-pyrimidin-7(8H)-one(1246200-01-0)
• EPA Substance Registry System: 6-(2-bromophenyl)-8-methyl-2-(methylthio)pyrido[2,3-d]-pyrimidin-7(8H)-one(1246200-01-0)

Safety Data

• Hazardous Substances Data: 1246200-01-0(Hazardous Substances Data)

Upstream product

• 2178-24-7 ethyl 2-(2-bromophenyl)ethanoate 
• 185040-32-8 4-methylamino-2-methylthiopyrimidine-5-carboxaldehyde 

Downstream Products

• 1246199-99-4 6-(2-bromophenyl)-8-methyl-2-(methylsulfonyl)pyrido[2,3-d]pyrimidin-7(8H)-one 

Relevant articles and documents

New effective inhibitors of the Abelson kinase

The effects of substituents on the aryl ring were studied by the preparation and testing of several PD173955 analogs. Inserting a single carbon atom into the C-N bond in the aniline subunit (PDC) reduced the kinase inhibition by a factor of 200. Despite its decreased affinity for Abl compared with PD173955, PDC exhibits a Ki very similar to that reported for Imatinib. Increased water solubility is also gained by replacing the thiomethyl group with an amino or glycyl moiety. For both PD173955 and PDC, the analogs with amino groups in place of the methylthio group are 10 times more inhibitory than the parent molecules. Two molecules were identified with Kis about three orders of magnitude lower than reported for Imatinib.