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1246213-33-1

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1246213-33-1 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1246213-33-1 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,4,6,2,1 and 3 respectively; the second part has 2 digits, 3 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 1246213-33:
(9*1)+(8*2)+(7*4)+(6*6)+(5*2)+(4*1)+(3*3)+(2*3)+(1*3)=121
121 % 10 = 1
So 1246213-33-1 is a valid CAS Registry Number.

1246213-33-1Relevant articles and documents

Altering metabolic profiles of drugs by precision deuteration 2: Discovery of a deuterated analog of ivacaftor with differentiated pharmacokinetics for clinical development

Harbeson, Scott L.,Morgan, Adam J.,Liu, Julie F.,Aslanian, Ara M.,Nguyen, Sophia,Bridson, Gary W.,Brummel, Christopher L.,Wu, Lijun,Tung, Roger D.,Pilja, Lana,Braman, Virginia,Uttamsingh, Vinita

, p. 359 - 367 (2018/11/23)

Ivacaftor is currently used for the treatment of cystic fibrosis as both monotherapy (Kalydeco; Vertex Pharmaceuticals, Boston, MA) and combination therapy with lumacaftor (Orkambi; Vertex Pharmaceuticals). Each therapy targets specific patient population

PROCESS FOR MAKING MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR

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Page/Page column 65; 70-71, (2010/10/03)

The invention provides a process for the preparation of a compound of Formula 1; comprising coupling a carboxylic acid of Formula 2; with an aniline of Formula 3; in the presence of a coupling agent.

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