1246261-57-3

Basic information

• Product Name: C₂₁H₃₀N₂O₇S
• Synonyms: C₂₁H₃₀N₂O₇S
• CAS NO: 1246261-57-3
• Molecular Weight: 454.544
• Mol File: 1246261-57-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₁H₃₀N₂O₇S(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₁H₃₀N₂O₇S(1246261-57-3)
• EPA Substance Registry System: C₂₁H₃₀N₂O₇S(1246261-57-3)

Safety Data

• Hazardous Substances Data: 1246261-57-3(Hazardous Substances Data)

Upstream product

• 40137-11-9 diethyl methylsulfonylmethylphosphonate 
• 1246261-47-1 C₁₉H₂₆N₂O₆ 

Downstream Products

• 1246261-42-6 C₁₇H₂₂N₂O₇S 

Relevant articles and documents

Synthesis and evaluation of vinyl sulfones as caspase-3 inhibitors. A structure-activity study

The first structure-activity relationship study of vinyl sulfones as caspase-3 inhibitors is reported. A series of 12 vinyl sulfones was synthesized and evaluated for two downstream caspases (caspases-3 and -7). Dipeptidyl derivatives were significantly superior to their counterparts containing only Asp at P1, as caspase-3 inhibitors. Fmoc-Val-Asp-trans-CHCH-SO 2Me was the most potent inhibitor of caspase-3 in the series, with a IC50 of 29 μM and a second-order rate constant of inactivation, kinact/Ki, of 1.5 M-1 s-1. Computational studies suggest that the second amino acid occupies position S3 of the enzyme. In addition, Fmoc-Val-Asp-trans-CHCH-SO 2Ph was inactive for caspase-7 for the tested concentrations. The first structure-activity relationship study of vinyl sulfones as caspase-3 inhibitors is reported. A series of 12 vinyl sulfones was synthesized and evaluated for caspase-3 inhibition.