1246365-03-6

Basic information

• Product Name: (Z)-1-methoxy-3-(2-methoxybenzylidene)-1,3-dihydroisobenzofuran
• CAS NO: 1246365-03-6
• Molecular Weight: 268.312
• Mol File: 1246365-03-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (Z)-1-methoxy-3-(2-methoxybenzylidene)-1,3-dihydroisobenzofuran(CAS DataBase Reference)
• NIST Chemistry Reference: (Z)-1-methoxy-3-(2-methoxybenzylidene)-1,3-dihydroisobenzofuran(1246365-03-6)
• EPA Substance Registry System: (Z)-1-methoxy-3-(2-methoxybenzylidene)-1,3-dihydroisobenzofuran(1246365-03-6)

Safety Data

• Hazardous Substances Data: 1246365-03-6(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 

Relevant articles and documents

Selective base-promoted synthesis of dihydroisobenzofurans by domino addition/annulation reactions of ortho-alkynylbenzaldehydes

Synthesis of the dihydroisobenzofuran nucleus was achieved by the base-promoted tandem nucleophilic addition/annulation reaction of ortho-alkynylbenzaldehydes in the presence of methanol. The reactions of aryl-, trimethylsilyl- and diethoxymethyl-substituted alkynylbenzaldehydes occurred with complete regioselectivity in good to excellent yields under microwave irradiation. The reactions of alkyl-substituted alkynylbenzaldehydes took place with good yields and high regioselectivity only when performed at room temperature and in the presence of a catalytic amount of a gold(III) salt. Plausible reaction mechanisms involved are discussed. The effect of the substituent at the alkynyl terminus on the cyclisation mode was tentatively rationalised. Georg Thieme Verlag Stuttgart · New York.