124655-07-8Relevant articles and documents
New Statin intermediate, the preparation of the same and the preparation of Rosuvastatin using the same
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Paragraph 0139; 0145-0147, (2017/04/20)
The present invention provides a novel producing method for producing a core intermediate (chemical formula IV) of rosuvastatin, a novel intermediate used therefor and a producing method of rosuvastatin hemi-calcium salts using the same. The novel intermediate of the present invention can be prepared with high purity and in high yields in mild conditions, and thus the rosuvastatin intermediate and rosuvastatin hemi-calcium salts can be conveniently and efficiently mass-produced without complicated processes.
NOVEL PROCESS FOR STEREOSELECTIVE REDUCTION OF ?-KETOESTERS
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Page 7-8, (2008/06/13)
A novel process for the preparation of compounds of formula (I): R1 = CN, OP (P=any suitable protecting group), alkyl, aryl or hetroaryl, R2 = Alkyl or aryl by reacting a compound of formula (II): R1 = CN, OP (P=any suitable protecting group), alkyl, aryl or hetroaryl, R2 = Alkyl or aryl with a reducing agent, sodium borohydride in presence of metal halides, preferably CeC13 or metal alkoxides, preferably Ti(OiPr)4.
Stereoselective synthesis of HR 780 a new highly potent HMG-CoA reductase inhibitor
Wess,Kesseler,Baader,Bartmann,Beck,Bergmann,Jendralla,Bock,Holzstein,Kleine,Schnierer
, p. 2545 - 2548 (2007/10/02)
HR 780 (1) a new HMG-CoA reductase inhibitor has been synthesized stereoselectively starting from L-malic acid. Wittig olefination employing phosphonium halides, phosphonates and phosphane oxides have been investigated.