124662-61-9

Basic information

• Product Name: 4-Pentyn-2-ol, 1-(phenylmethoxy)-, (2S)-
• CAS NO: 124662-61-9
• Molecular Formula: C12H14O2
• Molecular Weight: 190.242
• Mol File: 124662-61-9.mol
• Article Data: 16

Chemical Properties

• CAS DataBase Reference: 4-Pentyn-2-ol, 1-(phenylmethoxy)-, (2S)-(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Pentyn-2-ol, 1-(phenylmethoxy)-, (2S)-(124662-61-9)
• EPA Substance Registry System: 4-Pentyn-2-ol, 1-(phenylmethoxy)-, (2S)-(124662-61-9)

Safety Data

• Hazardous Substances Data: 124662-61-9(Hazardous Substances Data)

Upstream product

• 100-51-6 benzyl alcohol 
• 100-39-0 benzyl bromide 
• 14618-80-5 (R)-benzyl glycidol 
• 2930-05-4 (S)-benzyl glycidyl ether 
• 484664-27-9 (2S)-1-benzyloxy-5-trimethylsilanyl-pent-4-yn-2-ol 
• 1216963-74-4 lithium acetylide-ethylenediamine complex 
• 74-86-2 acetylene 
• 189386-93-4 (2R)-1-benzyloxy-2-hydroxy-5-(trimethylsilyl)-pent-4-yne 
• 70277-75-7 lithium acetylide 

Downstream Products

• 897961-94-3 (1S)-(1-benzyloxymethyl-but-3-ynyloxy)-triethyl-silane 
• 897961-25-0 (5S)-6-benzyloxy-5-triethylsilanyloxy-hex-2-ynal 
• 897961-27-2 (10S)-11-benzyloxy-10-triethylsilanyloxyundec-1-en-7-yn-6-ol 
• 897961-29-4 (10S)-11-benzyloxy-10-triethylsilanyloxyundec-1-en-7-yn-6-one 
• 897961-88-5 (9S)-10-benzyloxy-9-triethylsilanyloxydec-1-en-6-yn-5-ol 
• 897961-35-2 (9S)-10-benzyloxy-9-triethylsilanyloxydec-1-en-6-yn-5-one 
• 897961-39-6 (7S)-8-benzyloxy-1-oxiranyl-7-triethylsilanyloxyoct-4-yn-3-one 
• 897961-40-9 (2S)-1-benzyloxy-9-hydroxy-2-triethylsilanyloxy-12-trimethylsilanyldodeca-4,11-diyn-6-one 
• 897961-41-0 (2S)-1-benzyloxy-2,9-bistriethylsilanyloxy-12-trimethylsilanyldodeca-4,11-diyn-6-one 
• 897961-42-1 (2''S)-1-[2-(3-benzyloxy-2-triethylsilanyloxypropyl)-[1,3]-dithian-2-yl]-5-triethylsilanyloxy-8-trimethylsilanyl-oct-7-yn-2-one 
• 313677-42-8 (S)-1-((2R,7S)-7-Benzyloxymethyl-oxepan-2-yl)-2-(4-methoxy-benzyloxy)-ethanol 
• 313677-54-2 (S)-1-Benzyloxy-6-[(2S,3S)-3-(4-methoxy-benzyloxymethyl)-oxiranyl]-hex-4-yn-2-ol 
• 313677-40-6 (S)-1-Benzyloxy-6-[(2S,3S)-3-(4-methoxy-benzyloxymethyl)-oxiranyl]-hexan-2-ol 

Relevant articles and documents

Diastereoselective Alkene Hydroesterification Enabling the Synthesis of Chiral Fused Bicyclic Lactones

Palladium-catalysed diastereoselective hydroesterification of alkenes assisted by the coordinative hydroxyl group in the substrate afforded a variety of chiral γ-butyrolactones bearing two stereocenters. Employing the carbonylation-lactonization products as the key intermediates, the route from the alkenes with single chiral center to chiral THF-fused bicyclic γ-lactones containing three stereocenters was developed.

Highly stereoselective C-C bond formation by rhodium-catalyzed tandem ylide formation/[2,3]-sigmatropic rearrangement between donor/acceptor carbenoids and chiral allylic alcohols

The tandem ylide formation/[2,3]-sigmatropic rearrangement between donor/acceptor rhodium carbenoids and chiral allyl alcohols is a convergent C-C bond forming process, which generates two vicinal stereogenic centers. Any of the four possible stereoisomers can be selectively synthesized by appropriate combination of the chiral catalyst Rh2(DOSP)4 and the chiral alcohol.

First stereoselective synthesis of synargentolide A and revision of absolute stereochemistry

The first stereoselective total synthesis of synargentolide A isolated from Syncolostemon argenteus has been achieved from commercially available (R)-benzyl glycidyl ether using Sharpless asymmetric epoxidation and cross-metathesis reactions as the key st