124721-03-5

Basic information

• Product Name: platinum(4+) chloride hydroxide - cyclohexanamine ammoniate (1:2:2:1:1)
• CAS NO: 124721-03-5
• Molecular Formula: C₆H₁₈Cl₂N₂O₂Pt
• Molecular Weight: 416.2093
• Mol File: 124721-03-5.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 134.5°C at 760 mmHg
• Flash Point: 32.2°C
• Vapor Pressure: 8.07mmHg at 25°C
• CAS DataBase Reference: platinum(4+) chloride hydroxide - cyclohexanamine ammoniate (1:2:2:1:1)(CAS DataBase Reference)
• NIST Chemistry Reference: platinum(4+) chloride hydroxide - cyclohexanamine ammoniate (1:2:2:1:1)(124721-03-5)
• EPA Substance Registry System: platinum(4+) chloride hydroxide - cyclohexanamine ammoniate (1:2:2:1:1)(124721-03-5)

Safety Data

• Hazardous Substances Data: 124721-03-5(Hazardous Substances Data)

Upstream product

• 108-91-8 cyclohexylamine 
• 209861-57-4 C₆H₂₀N₂O₂Pt⁽²⁺⁾ 
• 7722-84-1 dihydrogen peroxide 
• 159701-67-4 cis-dichloro-trans-ammonia(cyclohexylamine)platinum 

Downstream Products

• 129580-63-8 (OC₆-6-22)-bis(acetato-O)amminedichloro(cyclohexylamine)platinum(IV) 
• 129580-63-8 (OC₆-6-12)-bis(acetato-O)amminedichloro(cyclohexylamine)platinum(IV) 
• 56-89-3 L-cystine 
• 1034767-14-0 trans-[Pt(OH)2(c-C₆H₁₁NH₂)(NH₃)] 
• 40055-98-9 oxidized glutathione 
• 312-10-7 DL-penicillamine disulfide 
• 56-89-3 cysteine disulfide 
• 4775-93-3 2,2'-dithiobispropanoic acid 
• 3384-95-0 3,4-dithia-hexane-1,2,5,6-tetracarboxylic acid 
• 5545-17-5 N,N'-diacetyl-L-cystine 
• 160953-30-0 (OC-6-43)-amminedichloro(cyclohexanamine)bis(ethyl carbonato-O)platinum(IV) 
• 129552-14-3 (OC-6-33)-amminedichloro(cyclohexanamine)bis(2,2-dimethylpropanoato-O)platinum(IV) 
• 129580-64-9 c-t-c-Pt(IV)Cl₂(O₂C-n-C₄H₉)2(NH₃)(c-C₆H₁₁NH₂) 
• 160953-33-3 (OC-6-43)-amminedichloro(cyclohexanamine)bis((methylthio)acetato-O)platinum(IV) 

Relevant articles and documents

Synthesis, characterization, and antitumor activity of novel tumor-targeted platinum(IV) complexes

Four tumor-targeted platinum(IV) complexes with ammonia and cyclohexylamine as the carrier groups and biotin as the axial group were designed, synthesized, and characterized. In vitro evaluation of the antitumor activity of complexes C1–C4 against lung cancer cells (A549), liver cancer cells (SMMC-7721), breast cancer cells (MCF-7), and colon cancer cells (SW480) was carried out. Complex C3 had the best cellular activity. Compared with cisplatin, complex C3 showed good anticancer activity against A549 cell line,complex C3 (6.34±0.44) is 3 times more cytotoxic than cisplatin (19.40±0.71),and against MCF-7 cell line complex C3 (4.22±0.11) is 5.4 times more cytotoxic than cisplatin (22.96±0.58), and against SW480 cell line complex C3 (6.65±0.60) is 3.4 times more cytotoxic than cisplatin (23.15±0.22). (Table 1) Axial chloride increased the redox power of complex C3 to increase the intercellular accumulation and the introduction of mixed amine had the ability to overcome cisplatin resistance. Complex C3 works best on MCF-7, then SW480, A549, and SMMC-7721. Thus, complex C3 is targeted by the axial introduction of biotin.

Chemical substance with anticancer activity and preparation method and application thereof

The invention discloses a chemical substance with anticancer activity and a preparation method and application thereof, belongs to the technical field of chemically-synthesized medicine, and aims to provide the chemical substance with low cytotoxicity, low drug resistance and high anticancer activity. The chemical substance is a compound as shown in formula (I), a compound as shown in formula (II) or the mixture of the compound as shown in formula (I) and the compound as shown in formula (II). The chemical substance has the advantages that the chemical substance is obtained by the mating reaction of artesunate and a platinum (IV) compound, the cytotoxicity of the platinum (IV) compound is lowered by introducing the artesunate ligand, the anticancer cavity of the platinum (IV) compound is increased, and the chemical substance is low in drug resistance and widely applicable to the preparation of anticancer medicine.

Crystal and Molecular Structures of Asymmetric cis- and trans-Platinum(II/IV) Compounds and Their Reactions with DNA Fragments

The asymmetrically substituted platinum(II) complexes cis-Pt(NH3)(c-C5H11NH2)Cl 2 and trans-Pt(NH3)(c-C6H11-NH2)Cl 2 have been synthesized and their crystal structures have been determined. Crystals of cis-Pt(NH3)(c-C6H11NH2)Cl 2 (1) are orthorhombic, space group Pbca (no. 61) with a = 10.1994(12), b = 10.494(2), c = 18.826(2) ?, Z = 8. The structure refinement converged to R1 = 0.0518 and wR2 = 0.1143. Crystals of trans-Pt(NH3)(c-C6H11NH2)Cl 2 (2) are monoclinic, space group P21/c (no. 14) with a = 12.141(3), b = 6.0965(9), c = 19.864(3) ?, β= 118.71(2)°, Z = 4. The structure refinement converged to R1 = 0.0711 and wR2 = 0.1846. In addition, the Pt(IV) analogues with axial hydroxide ligands have been synthesized. Also the corresponding bis(carboxylato)-platinum(IV) compound of formula trans,cis,cis-Pt(NH3)(c-C6H11NH 2)Cl2(OOCCH3)2 has been obtained by conversion of the hydroxide with acetic anhydride. Reactions of these platinum complexes with 9-methylhy-poxanthine and guanosine-5′-monophosphate (5′-GMP) have been studied in significant detail. The course of the reactions was followed by NMR spectroscopy, and 1H and 195Pt techniques were used to identify the formation of the products. It was found that the Pt(II) compounds easily react with the bases at the N7 position, whereas the Pt(IV) compounds react very slowly (for trans,cis,cis-Pt(NH3)(c-C6H11NH 2)Cl2(OOCCH3)2) or not at all (for trans,trans,trans-Pt(NH3)(c-C6H11NH 2)Cl2(OH)2). Only in the presence of glutathione does a reaction of the latter with 5′-GMP takes place. In this case a major product was found to be the reduced trans-Pt(II) complex with one molecule of 5′-GMP and one molecule of S-bonded glutathione.