124729-57-3Relevant articles and documents
Synthesis of bile acid analogs: 7-alkylated chenodesoxycholic acids
Une, Mizohu,Yamanaga, Katsumi,Mosbach, Erwin H.,Kuroki, Syoji,Hoshita, Takahiko
, p. 97 - 106 (1989)
This paper describes a method for the preparation of 7-alkylated chenodesoxycholic acids from 3α-hydroxy-7-oxo-5β-cholanoic acid.The synthetic procedure is based upon Grignard reaction between the keto bile acid and an alkyl magnesium halide.Under the conditions employed, the introduction of alkyl groups is highly stereoselective.Only 7β-alkylated epimers are obtained.The overall yield is several-fold higher than that obtained by the previous method, which involved the preparation of an oxazoline intermediate.
Chemical synthesis
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, (2008/06/13)
A process for the production of disubstituted bile acid analogs, including the disubstituted analogs of such bile acids as, lithocholic, hyodeoxycholic, cholic, chenodeoxycholic and ursodeoxycholic acids. This invention was made in the course of work performed under a grant from the U.S. National Heart Lung and Blood Institute.