1247822-22-5

Basic information

• Product Name: 2,2-difluoro-3-hydroxy-1,5-diphenylpentan-1-one
• Synonyms: 2,2-difluoro-3-hydroxy-1,5-diphenylpentan-1-one
• CAS NO: 1247822-22-5
• Molecular Weight: 290.31
• Mol File: 1247822-22-5.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2,2-difluoro-3-hydroxy-1,5-diphenylpentan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2-difluoro-3-hydroxy-1,5-diphenylpentan-1-one(1247822-22-5)
• EPA Substance Registry System: 2,2-difluoro-3-hydroxy-1,5-diphenylpentan-1-one(1247822-22-5)

Safety Data

• Hazardous Substances Data: 1247822-22-5(Hazardous Substances Data)

Upstream product

• 172027-15-5 Phenyl-[3-phenyl-prop-(E)-ylidene]-amine 
• 86340-78-5 2,2-difluoro-1-phenyl-1-trimethylsiloxyethene 
• 114701-62-1 ethyl 2,2-difluoro-3-oxo-3-phenylpropanoate 
• 92207-60-8 ethyl 2,2-difluoro-3-hydroxy-3-phenylpropanoate 
• 104-53-0 3-phenyl-propionaldehyde 
• 100-52-7 benzaldehyde 

Relevant articles and documents

An expedient synthesis of α,α-difluoro-β-hydroxy ketones via decarboxylative aldol reaction of α,α-difluoro-β-keto acids with aldehydes

A novel decarboxylative aldol reaction of α,α-difluoro-β-keto acids with aldehydes in the absence of any base and metal catalysts has been developed. This reaction provides a highly convenient and efficient method for the synthesis of structurally diverse α,α-difluoro-β-hydroxy ketones in good to excellent yields.

Preparation method of alpha,alpha-difluoro-beta-hydroxyketone compound

The invention belongs to the technical field of organic synthesis, and in particular relates to a preparation method of an alpha,alpha-difluoro-beta-hydroxyketone compound. An alpha,alpha-difluoro-beta-ketonic acid compound and an aldehyde compound R2CHO react for 10h to 16h in an organic solvent at the temperature of 90 DEG C to 120 DEG C for 10 to 16 hours to prepare the alpha,alpha-difluoro-beta-hydroxyketone compound. The preparation method provided by the invention has the advantages that raw materials are cheap and easy to obtain, and reaction conditions are moderate; a reaction can be carried out without the need of adding any inorganic alkali and a metal catalyst; the reaction is easy to operate, after-treatment is simple, the yield of a product is high, a few of side reactions occur and an applicable range is wide; the whole preparation method is green and environmentally friendly and has a very good application prospect.