124831-37-4

Basic information

• Product Name: cis-4-oxo-3-[(phenoxyacetyl)amino]-2-azetidinepropanoic acid
• Synonyms: cis-4-oxo-3-[(phenoxyacetyl)amino]-2-azetidinepropanoic acid
• CAS NO: 124831-37-4
• Molecular Weight: 292.291
• Mol File: 124831-37-4.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: cis-4-oxo-3-[(phenoxyacetyl)amino]-2-azetidinepropanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: cis-4-oxo-3-[(phenoxyacetyl)amino]-2-azetidinepropanoic acid(124831-37-4)
• EPA Substance Registry System: cis-4-oxo-3-[(phenoxyacetyl)amino]-2-azetidinepropanoic acid(124831-37-4)

Safety Data

• Hazardous Substances Data: 124831-37-4(Hazardous Substances Data)

Upstream product

• 99333-65-0 1-benzyl-3β-((S)-2-oxo-4-phenyloxazolidin-3-yl)-4β-[2-(2-furyl)ethyl]azetidin-2-one 
• 359015-21-7 (2S,3R)-2-Azido-6-benzyloxy-3-tert-butoxycarbonylamino-hexanoic acid ethyl ester 
• 359015-25-1 N-[(2R,3S)-2-(3-Benzyloxy-propyl)-4-oxo-azetidin-3-yl]-2-phenoxy-acetamide 
• 359015-31-9 (2R,3R)-6-Benzyloxy-3-tert-butoxycarbonylamino-2-hydroxy-hexanoic acid ethyl ester 
• 359015-17-1 (2S,3R)-6-benzyloxy-3-tert-butoxycarbonylamino-2-hydroxy-hexanoic acid 
• 359015-23-9 (3S,4R)-3-Azido-4-(3-benzyloxy-propyl)-azetidin-2-one 
• 133407-67-7 ethyl (E)-6-(benzyloxy)hex-2-enoate 
• 133789-03-4 N-((2R,3S)-2-But-3-enyl-4-oxo-azetidin-3-yl)-2-phenoxy-acetamide 
• 124831-36-3 N-[(2R,3S)-2-(2-Furan-2-yl-ethyl)-4-oxo-azetidin-3-yl]-2-phenoxy-acetamide 

Downstream Products

• 124831-39-6 (6R,7S)-3-Chloro-7-[(R)-2-((E)-2-methoxycarbonyl-1-methyl-vinylamino)-2-phenyl-acetylamino]-8-oxo-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-nitro-benzyl ester 
• 119892-48-7 cis-α-diazo-β,4-dioxo-3-[(phenoxyacetyl)amino]-2-azetidinepentanoic acid, (4-nitrophenyl)methyl ester 
• 119892-46-5 p-nitrobenzyl 7β-[(phenoxyacetyl)amino]-3-hydroxy-1-carba-1-dethia-3-cephem-4-carboxylate 
• 76470-66-1 loracarbef 
• 123932-46-7 carbacephalosporin hydrochloride 
• 299208-66-5 N-[(2R,3S)-2-(2-Cyano-ethyl)-1-cyanomethyl-4-oxo-azetidin-3-yl]-2-phenoxy-acetamide 
• 124831-38-5 cis-β,4-dioxo-3-[(phenoxyacetyl)amino]-2-azetidinepentanoic acid, (4-nitrophenyl)methyl ester 

Relevant articles and documents

An asymmetric aminohydroxylation approach to the stereoselective synthesis of cis-substituted azetidinone of loracarbef

A formal synthesis of loracarbef is described. The required key cis-substituted azetidinone skeleton was stereoselectively constructed via β-amino acid, which was provided from the asymmetric aminohydroxylation of α,β-unsaturated ester.

Process for preparing 4-substituted azetidinones

A process for preparing 3-4-cis-β,β-(4)-substituted and 3-4-trans,β,α- (4)-substituted azetidinones is provided. Also provided are novel 4,4-disubstituted azetidinones.

AN ENANTIOSELECTIVE SYNTHESIS OF LORACARBEF (LY163892/KT3777)

An enantioselective synthesis of the new, orally absorbable, totally synthetic β-lactam antibiotic, loracarbef(LY163892/KT3777) is described.