124856-99-1

Basic information

• Product Name: 2'-Aminochalcone Epoxide
• Synonyms: 2'-Aminochalcone Epoxide
• CAS NO: 124856-99-1
• Molecular Weight: 239.274
• Mol File: 124856-99-1.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 2'-Aminochalcone Epoxide(CAS DataBase Reference)
• NIST Chemistry Reference: 2'-Aminochalcone Epoxide(124856-99-1)
• EPA Substance Registry System: 2'-Aminochalcone Epoxide(124856-99-1)

Safety Data

• Hazardous Substances Data: 124856-99-1(Hazardous Substances Data)

Upstream product

• 78396-00-6 1-(2-aminophenyl)-3-phenylprop-2-en-1-one 
• 551-93-9 2-aminoacetophenone 
• 100-52-7 benzaldehyde 
• 78396-00-6 2-aminochalcone 

Downstream Products

• 124857-14-3 cis-1,2,3,4-Tetrahydro-3-hydroxy-2-phenyl-4-quinolone 
• 124857-16-5 2'-Amino-α-hydroxy-β-ethoxydihydrochalcone 
• 124857-00-7 2'-Acetamidochalcone Epoxide 
• 124857-01-8 2'-(Benzenesulfonamido)chalcone Epoxide 
• 124857-15-4 cis-3-Acetoxy-1-acetyl-1,2,3,4-tetrahydro-2-phenyl-4-quinolone 
• 25410-99-5 3-phenylquinolin-4(1H)-one 
• 6319-32-0 4-chloro-3-phenylquinoline 
• 56857-96-6 1-methyl-3-phenylquinolin-4(1H)-one 
• 1258792-41-4 1,3-diphenylquinolin-4(1H)-one 
• 136490-86-3 erythro-2-hydroxy-3-methoxy-1-(2'-aminophenyl)-3-phenylpropan-1-one 
• 136490-87-4 threo-1-(2'-aminobenzoyl)-2-phenylethylene chlorohydrin 
• 1412455-19-6 3-bromo-2-phenyl-2,3-dihydroquinolin-4(1H)-one 

Relevant articles and documents

Azaisoflavones: Synthesis, antimicrobial evaluation and binding affinity with DNA gyrase

Antimicrobial potency of azaisoflavones has been evaluated in vitro against nine bacterial and two fungal strains, respectively. The requisite azaisoflavones are conveniently synthesized in three steps, with the key step being the super acid catalyzed tandem reaction. The biological results reveal that out of twelve compounds screened, 3 compounds (5a, 5j and 5l) exhibited comparable activities against the standard drugs and demonstrated activities at μM concentration. In addition, molecular docking revealed that compound 5a as the most potent by showing a least binding energy of -5.99 kcal/mol with DNA gyrase receptor compared to other compounds.

Synthesis and fluorescence properties of 2-aryl-3-hydroxyquinolones, a new class of dyes displaying dual fluorescence

A series of 2-aryl-3-hydroxyquinolones (3HQs) with different electron donating aryl substituents at the position 2 were synthesized. Their absorption and fluorescence properties were studied in solvents of medium and high polarity. Almost all the synthesi

Ring closing and photooxidation in nitrogen analogues of 3-hydroxyflavone

An epoxide intermediate in the Algar-Flynn-Oyamada (AFO) synthesis of flavones is reaffirmed through the use of quinolone analogues to 3-hydroxyflavone (3HF).Stepwise synthesis of analogues 3-hydroxy-2-phenyl-1,4-dihydro-4-quinolone 11 and 3-hydroxy-1-methyl-2-phenyl-1,4-dihydro-4-quinolone 12, via chalcone formation, epoxidation, ring closing and final oxidation, has been accomplished.The intermediacy of an epoxide is further supported by blocking cyclization with methoxy substitution at the 2'-position (1A).Absorption/emission spectroscopy of 11 and 12 shows large red shifts, as seen in 3HF, indicative of an excited state intramolecular proton transfer mechanism.Nitrogen analogues demonstrate photooxidative stability similar to that of 3HF.