124898-12-0

Basic information

• Product Name: Silane, trimethyl(2,2,2-trifluoro-1-phenylethoxy)-
• CAS NO: 124898-12-0
• Molecular Formula: C11H15F3OSi
• Molecular Weight: 248.32
• Mol File: 124898-12-0.mol
• Article Data: 33

Chemical Properties

• CAS DataBase Reference: Silane, trimethyl(2,2,2-trifluoro-1-phenylethoxy)-(CAS DataBase Reference)
• NIST Chemistry Reference: Silane, trimethyl(2,2,2-trifluoro-1-phenylethoxy)-(124898-12-0)
• EPA Substance Registry System: Silane, trimethyl(2,2,2-trifluoro-1-phenylethoxy)-(124898-12-0)

Safety Data

• Hazardous Substances Data: 124898-12-0(Hazardous Substances Data)

Upstream product

• 100-52-7 benzaldehyde 
• 289706-46-3 4-[2,2,2-trifluoro-1-(trimethylsilyloxy)ethyl]morpholine 
• 13411-48-8 1-(trimethylsilyl)ethanone 
• 81290-20-2 (trifluoromethyl)trimethylsilane 
• 848572-70-3 Trifluoro-methanesulfinic acid benzyl-((1R,2S)-1,2-diphenyl-2-trimethylsilanyloxy-ethyl)-amide 
• 848572-62-3 N-(1,2-diphenyl-2-trimethylsilanyloxy-ethyl)-2,2,2-trifluoro-N-methyl-acetamide 
• 848572-61-2 N-(1,2-diphenyl-2-trimethylsilanyloxy-ethyl)-2,2,2-trifluoro-N-methyl-acetamide 
• 848572-72-5 Trifluoro-methanesulfinic acid benzyl-((1S,2R)-1-methyl-2-phenyl-2-trimethylsilanyloxy-ethyl)-amide 
• 497937-77-6 N-trifluoroacetyl-O-trimethylsilylephedrine 
• 497937-81-2 N-benzyl-2,2,2-trifluoro-N-(2-trimethylsilanyloxy-ethyl)-acetamide 
• 602331-46-4 2,2,2-trifluoro-N-methyl-N-(2-phenyl-2-trimethylsilanyloxy-ethyl)-acetamide 
• 497937-80-1 2,2,2-trifluoro-N-methyl-N-(2-trimethylsilanyloxy-ethyl)-acetamide 
• 75-77-4 chloro-trimethyl-silane 
• 345959-36-6 1-(4-benzylpiperazin-1-yl)-2, 2, 2-trifluoroethanol 

Downstream Products

• 10531-50-7 (R)-2,2,2-trifluoro-1-phenylethanol 
• 340-06-7 S(+)-1-phenyl-2,2,2-trifluoroethanol 
• 340-04-5 1-phenyl-2,2,2-trifluoromethylethanol 

Relevant articles and documents

Synthesis of Trifluoromethylated Dithiocarbamates via Photocatalyzed Substitution Reaction: Pentafluoropyridine as Activating Reagent

A method for the synthesis of trifluoromethyl-substituted dithiocarbamates from aldehydes is described. The reaction involves nucleophilic trifluoromethylation, derivatization of the silyloxy-group with pentafluoropyridine, and substitution of the fluorin

Tri-tert-butylphosphine is an efficient promoter for the trifluoromethylation reactions of aldehydes, ketones, imides and imines

A truly catalytic nucleophilic trifluoromethylation reaction of carbonyl compounds with Ruppert's reagent, Me3SiCF3, has been shown to be efficiently promoted by a P(t-Bu)3-DMF system. Imines were also converted to the des

Organoelement compounds in the electrochemical synthesis of fluoroorganics

Electrochemical generation of organic anion-radicals in the presence of fluoroorganosilanes causes the chain addition reaction. Adducts of CFCl2SiMe3, CFCl=CFSiMe3 and CF3SiMe3 with benzaldehyde were

Tbd-catalyzed trifluoromethylation of carbonyl compounds with (trifluoromethyl)-trimethylsilane

Trifluoromethylation of carbonyl compounds using (trifluoromethyl) trimethylsilane catalyzed by 1,5,7-triazabicyclo[4,4,0]dec-5-ene (TBD) afforded the corresponding a-trifluoromethyl alcohols in good to excellent yields under mild reaction conditions. Sup

MgCl2-catalyzed trifluoromethylation of carbonyl compounds using (trifluoromethyl)trimethylsilane as the trifluoromethylating agent

Using (trifluoromethyl)trimethylsilane (TMSCF3) as the trifluoromethylating agent, MgCl2-catalyzed trifluoromethylation of carbonyl compounds proceeded readily at room temperature. In the presence of 10 mol% of MgCl2, a variety of carbonyl substrates such as aliphatic/aromatic aldehydes, acyclic/cyclic ketones and esters could be trifluoromethylated in DMF, giving the corresponding trimethylsilyl ethers (ketals) in up to 93% isolated yields. Trifluoromethylketones could be readily obtained after hydrolysis of the trimethylsilyl ketals. The reactions could tolerate air and moisture, and the use of oxygen and moisture-free conditions was not required.

PERFLUORORALKYLATION OF CARBONYL COMPOUNDS

The present invention provides a process for producing a compound comprising a perfluorinated alkyl group moiety from a carbonyl compound. Typically, the process includes contacting a carbonyl compound with a silane compound in the presence of a fluorohydrogenate ionic liquid under conditions sufficient to produce a compound comprising a perfluorinated alkyl group. The silane compound includes a perfluoroalkyl group.