124898-13-1 Usage
Description
(PENTAFLUOROETHYL)TRIMETHYLSILANE, also known as Trimethylpentafluoroethylsilane, is a perfluoroalkylsilane compound characterized by its unique structure and reactivity. It possesses a pentafluoroethyl group attached to a trimethylsilyl moiety, which grants it distinct properties and makes it a versatile reagent in various chemical reactions.
Uses
Used in Pharmaceutical Industry:
(PENTAFLUOROETHYL)TRIMETHYLSILANE is used as a silicon-based fluorinating reagent for the trifluoromethylation of carbonyls and ethylene diamines. This application is crucial in the synthesis of various pharmaceutical compounds, as the trifluoromethyl group is a common structural element in many drugs, providing enhanced metabolic stability and bioavailability.
Used in Chemical Synthesis:
(PENTAFLUOROETHYL)TRIMETHYLSILANE is used as a precursor for metal-mediated trifluoromethylation of aromatic, heteroaromatic, and vinyl substrates. This versatile reagent enables the introduction of the trifluoromethyl group into a wide range of organic molecules, which is essential for the development of new materials and compounds with improved properties.
Used in Synthesis of Quinoline Derivatives:
(PENTAFLUOROETHYL)TRIMETHYLSILANE serves as a perfluoroalkylating reagent in the synthesis of specific quinoline derivatives, such as 5-bromo-2-(perfluoroethyl)quinoline, 8-methoxy-2-(perfluoroethyl)quinoline, 1-(perfluoroethyl)isoquinoline, and 8-(tert-butoxy)-5,7-dichloro-2-(perfluoroethyl)quinolone. These compounds have potential applications in various fields, including pharmaceuticals and materials science.
Used in Synthesis of Pentafluoroethylcyclohexanes:
(PENTAFLUOROETHYL)TRIMETHYLSILANE is also utilized in the synthesis of pentafluoroethylcyclohexanes, which are valuable intermediates in the production of various specialty chemicals and materials with unique properties, such as enhanced chemical stability and improved performance in specific applications.
Check Digit Verification of cas no
The CAS Registry Mumber 124898-13-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,4,8,9 and 8 respectively; the second part has 2 digits, 1 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 124898-13:
(8*1)+(7*2)+(6*4)+(5*8)+(4*9)+(3*8)+(2*1)+(1*3)=151
151 % 10 = 1
So 124898-13-1 is a valid CAS Registry Number.
InChI:InChI=1/C5H9F5Si/c1-11(2,3)5(9,10)4(6,7)8/h1-3H3
124898-13-1Relevant articles and documents
Structural Characterization of Hydro-, Chloro- and Fluoroorganylsilanes with Substituents of Varying Electron Withdrawing Character
Ke?ler, Mira,Porath, Sven,Stammler, Hans-Georg,Hoge, Berthold
, p. 907 - 913 (2021)
We report on the molecular structure of trimethylsilanes Si(CH3)3X in which the substituents X, namely (Z)-pentafluoropropen-1-yl, trifluoropropyn-1-yl, pentafluoroethyl, trifluorovinyl, vinyl, propyn-1-yl, di- and trichloromethyl, display electron withdrawing effects of varying strength. The lengths of the bonds between the silicon and the carbon atoms of X correlate with the hybridization of the respective orbitals and the steric demand of X rather than with the electron withdrawing capability. In case of chlorinated substituents dispersion effects seem to shorten the Si?C bond. Furthermore, a route for generating trifluoropropyn-1-yllithium from the cryogen 2,3,3,3-tetrafluoropropene (HFO-1234yf) and n-butyllithium is described. Tetrafluoropropen-1-yllithium is slowly formed at ?80 °C but even at this temperature spontaneous elimination of LiF occurs. Deprotonation of the formed 3,3,3-trifluoropropyne requires temperatures of above ?60 °C leading to trifluoropropyn-1-yllithium which appears as relatively stable at room temperature.
NOVEL AROMATIC COMPOUNDS
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Page/Page column 108; 109, (2018/09/19)
The present invention comprises novel aromatic molecules, which can be used in the treatment of pathological conditions, such as cancer, skin diseases, muscle disorders, and immune system-related disorders such as disorders of the hematopoietic system including the hematologic system in human and veterinary medicine.
Process for preparing polyfluoroalkylithium compounds
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Page/Page column 5, (2010/02/11)
The invention relates to a process for preparing polyfluoroalkyl-lithium compounds by deprotonation of polyfluoroalkyl compounds by means of lithium bases.
