124908-16-3

Basic information

• Product Name: 1-phenylethyl thiocyanate
• CAS NO: 124908-16-3
• Molecular Weight: 163.243
• Mol File: 124908-16-3.mol
• Article Data: 22

Chemical Properties

• CAS DataBase Reference: 1-phenylethyl thiocyanate(CAS DataBase Reference)
• NIST Chemistry Reference: 1-phenylethyl thiocyanate(124908-16-3)
• EPA Substance Registry System: 1-phenylethyl thiocyanate(124908-16-3)

Safety Data

• Hazardous Substances Data: 124908-16-3(Hazardous Substances Data)

Upstream product

• 505-14-6 thiocyanogen 
• 100-41-4 ethylbenzene 
• 1147550-11-5 ammonium thiocyanate 
• 672-65-1 (1-chloroethyl)benzene 
• 333-20-0 potassium thioacyanate 
• 585-71-7 (1-bromoethyl)benzne 
• 98-85-1 1-Phenylethanol 
• 540-72-7 sodium thiocyanide 
• 2290-65-5 trimethylsilyl isothiocyanate 
• 163276-49-1 1-thiocyanatopyrrolidine-2,5-dione 
• 557-42-6 zinc(II) thiocyanate 
• 98-86-2 acetophenone 
• 105966-39-0 2-(1-phenylethoxy)-tetrahydro-2H-pyran 
• 14856-75-8 1-phenyl-1-trimethylsilyloxyethane 

Downstream Products

• 24277-44-9 (1-isothiocyanato-ethyl)-benzene 
• 33877-11-1 1-Phenylethanethiol 
• 86963-42-0 α-phenylethanesulfonic acid 
• 345927-66-4 (2,4-dinitro-phenyl)-(1-phenyl-ethyl)-sulfide 

Relevant articles and documents

AIBN-initiated direct thiocyanation of benzylic sp3C-H with: N -thiocyanatosaccharin

Direct thiocyanations of benzylic compounds have been implemented. Here, a new strategy, involving a free radical reaction pathway initiated by AIBN, was used to construct the benzylic sp3 C-SCN bond. In this way, the disadvantage of other strategies involving introducing leaving groups in advance to synthesize benzyl thiocyanate compounds was overcome. The currently developed protocol also involved the use of readily available raw materials and resulted in high product yields (up to 100%), both being great advantages for synthesizing benzyl thiocyanates.

Preparation method for alpha-benzene methane sulfonic acid derivative with optical activity

The invention discloses a preparation method for alpha-benzene methane sulfonic acid derivative with optical activity. The preparation method comprises the following steps: Step A: mixing a sodium thiocyanate aqueous solution with compound (I) to react, carrying out postprocessing after reaction is finished to obtain a compound (II); Step B: mixing the compound (II), acetic acid and concentrated sulfuric acid, carrying out oxidation reaction after hydrogen peroxide is added, and carrying out postprocessing after reaction is finished to obtain the alpha-benzene methane sulfonic acid derivative. According to the preparation method, the sodium thiocyanate is adopted as an reaction reagent, reaction yield is effectively improved, and meanwhile, preparation method is simple in operation, is friendly to environment and is easy in carrying out industrial production.

2,4,4,6-Tetrabromo-2,5-cyclohexadienone as an efficient reagent for phosphine-free electrophilic transformation of alcohols and epoxides

In this study, 2,4,4,6-tetrabromo-2,5-cyclohexadienone (TABCO) was prepared and used successfully as a stable phosphine-free reagent for the conversion of alcohols into alkyl thiocyanates and epoxides into 2-hydroxythiocyanates. The reactions seem to proceed via in situ generation of electrophilic sulfur species by reaction of NH4SCN and TABCO. This combined reagent worked well with both alcohols and epoxides in acetonitrile solvent and under solvent-free conditions.