124915-09-9Relevant articles and documents
Novel synthesis of [18F]-fluorobenzene and pyridinecarbohydrazide-folates as potential PET radiopharmaceuticals
Al Jammaz,Al-Otaibi,Okarvi,Amartey
, p. 125 - 137 (2006)
In an attempt to visualize folate receptors that over-express on many cancers, [18F]-fluorobenzene and pyridine carbohydrazide-folates were synthesized using two different synthetic approaches starting from nucleophilic displacement reactions on ethyl-trimethylammonium-benzoate and pyridine carboxylate precursors. The intermediates ethyl [18F]-fluorinated benzene and pyridine esters were reacted with hydrazine to produce the [ 18F]-fluorobenzene and pyridine carbohydrazides followed by coupling with NHS-folate 11 in the first approach. Whereas hydrazide-folate 5 was reacted with 2,5-dioxoazolidinyl [18F]-fluorobenzenecarboxylate in the second approach. Based on starting [18F]-fluoride, radiochemical yields and synthesis times were found to be around 80% (45 min) and 35% (80 min) for the first and the second approaches, respectively. The first synthetic approach holds considerable promise as a rapid and simple method for the radiofluorination of folic acid with high radiochemical yield and short time. Copyright
An improved synthesis of n-(4-[18 f]fluorobenzoyl)-interleukin-2 for the preclinical pet imaging of tumour-infiltrating t-cells in ct26 and mc38 colon cancer models
Cheng, Peter,Goggi, Julian L.,Hartimath, Siddesh V.,Jiang, Lingfan,Khanapur, Shivashankar,Narayanaswamy, Pradeep,Ramasamy, Boominathan,Robins, Edward George,Yong, Fui Fong
, (2021/06/16)
Positron emission tomography (PET) imaging of activated T-cells with N-(4-[18 F]fluorobenzoyl)-interleukin-2 ([18 F]FB-IL-2) may be a promising tool for patient management to aid in the assessment of clinical responses to immune ther
On-demand radiosynthesis of: N -succinimidyl-4-[18F]fluorobenzoate ([18F]SFB) on an electrowetting-on-dielectric microfluidic chip for 18F-labeling of protein
Kim, Hee-Kwon,Javed, Muhammad Rashed,Chen, Supin,Zettlitz, Kirstin A.,Collins, Jeffrey,Wu, Anna M.,Kim, Chang-Jin,Michael Van Dam,Keng, Pei Yuin
, p. 32175 - 32183 (2019/10/21)
An all-electronic, droplet-based batch microfluidic device, operated using the electrowetting on dielectric (EWOD) mechanism was developed for on-demand synthesis of N-succinimidyl-4-[18F]fluorobenzoate ([18F]SFB), the most commonly
Chemoselective Radiosyntheses of Electron-Rich [18F]Fluoroarenes from Aryl(2,4,6-trimethoxyphenyl)iodonium Tosylates
Kwon, Young-Do,Son, Jeongmin,Chun, Joong-Hyun
, p. 3678 - 3686 (2019/03/11)
Hypervalent diaryliodonium salts have been used to produce various [18F]fluoroarenes. The iodonium salt approach as a labeling precursor has been established to equally afford complex 18F-fluorinated molecules. Because of the inheren
