1249400-92-7

Basic information

• Product Name: 5-(2-(Dimethylamino)ethoxy)pyridin-2-amine
• Synonyms: 5-(2-(Dimethylamino)ethoxy)pyridin-2-amine
• CAS NO: 1249400-92-7
• Molecular Weight: 181.238
• Mol File: 1249400-92-7.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 5-(2-(Dimethylamino)ethoxy)pyridin-2-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(2-(Dimethylamino)ethoxy)pyridin-2-amine(1249400-92-7)
• EPA Substance Registry System: 5-(2-(Dimethylamino)ethoxy)pyridin-2-amine(1249400-92-7)

Safety Data

• Hazardous Substances Data: 1249400-92-7(Hazardous Substances Data)

Usage

General Description

5-(2-(Dimethylamino)ethoxy)pyridin-2-amine is a chemical compound with the molecular formula C9H14N3O. It is a pyridine derivative containing a dimethylamino group and an ethoxy group attached to the 5th position of the pyridine ring, as well as an amine group at the 2nd position. 5-(2-(Dimethylamino)ethoxy)pyridin-2-amine is used in organic synthesis and medicinal chemistry, and it may have potential applications in the development of pharmaceutical drugs or as a research tool in the study of biological systems. Its specific properties and potential uses would depend on further investigation and testing.

Upstream product

• 228710-82-5 5-bromo-2-(2,5-dimethyl-pyrrol-1-yl)-pyridine 
• 55717-45-8 6-bromo-pyridin-3-ol 
• 1346675-75-9 dimethyl-[2-(6-nitropyridin-3-yloxy)ethyl]amine 
• 15206-26-5 2-nitro-5-hydroxypyridine 
• 779345-37-8 5-fluoro-2-nitro-pyridine 

Downstream Products

• 1346675-77-1 {2-[5-({5-[2-(dimethylamino)ethoxy]pyridin-2-yl}amino)-1-methyl-6-oxo-1,6-dihydropyridin-3-yl]-4-fluoro-6-{6-oxo-8-thia-5-azatricyclo[7.4.0.0(2,7)]trideca-1⁽⁹⁾,2⁽⁷⁾-dien-5-yl}phenyl}methyl acetate 
• 1346671-16-6 5-{3-[5-({5-[2-(dimethylamino)ethoxy]pyridin-2-yl}amino)-1-methyl-6-oxo-1,6-dihydropyridin-3-yl]-5-fluoro-2-(hydroxymethyl)phenyl}-8-thia-5-azatricyclo[7.4.0.0(2,7)]trideca-1⁽⁹⁾,2⁽⁷⁾-dien-6-one 

Relevant articles and documents

Discovery of 4,6-disubstituted pyrimidines as potent inhibitors of the heat shock factor 1 (HSF1) stress pathway and CDK9

Heat shock factor 1 (HSF1) is a transcription factor that plays key roles in cancer, including providing a mechanism for cell survival under proteotoxic stress. Therefore, inhibition of the HSF1-stress pathway represents an exciting new opportunity in cancer treatment. We employed an unbiased phenotypic screen to discover inhibitors of the HSF1-stress pathway. Using this approach we identified an initial hit (1) based on a 4,6-pyrimidine scaffold (2.00 μM). Optimisation of cellular SAR led to an inhibitor with improved potency (25, 15 nM) in the HSF1 phenotypic assay. The 4,6-pyrimidine 25 was also shown to have high potency against the CDK9 enzyme (3 nM).

CYCLIN-DEPENDENT KINASE INHIBITORS

Described herein are compounds and their pharmaceutically acceptable salts, pharmaceutical compositions thereof, methods of treatment, and medical uses. The compounds described herein are modulators of cyclin-dependent kinases, and are useful in the treatment or alleviation of protein kinase associated disorders, including cancer, infectious diseases, autoimmune diseases, or cardiovascular diseases.

CYCLIN-DEPENDENT KINASE INHIBITORS

Described herein are compounds and their pharmaceutically acceptable salts, pharmaceutical compositions thereof, methods of treatment, and medical uses. The compounds described herein are modulators of cyclin-dependent kinases, and are useful in the treatment or alleviation of protein kinase associated disorders, including cancer, infectious diseases, autoimmune diseases, or cardiovascular diseases.