125-51-9 Usage
Description
Piperidinium,1-ethyl-3-[(2-hydroxy-2,2-diphenylacetyl)oxy]-1-methyl-, bromide (1:1) is a complex organic compound with a unique structure that features a piperidine ring, an ethyl group, a hydroxy-diphenylacetyloxy group, and a methyl group. It is characterized by its bromide salt form, which is essential for its properties and applications.
Uses
Used in Pharmaceutical Industry:
Piperidinium,1-ethyl-3-[(2-hydroxy-2,2-diphenylacetyl)oxy]-1-methyl-, bromide (1:1) is used as an antispasmodic agent for the treatment of various conditions that involve muscle spasms and involuntary contractions. Its unique structure allows it to interact with cellular targets, leading to a reduction in muscle spasms and providing relief to patients.
Used in Cancer Therapy:
In the field of cancer therapy, Piperidinium,1-ethyl-3-[(2-hydroxy-2,2-diphenylacetyl)oxy]-1-methyl-, bromide (1:1) is used in combination with copper-tolylterpyridine and platinum-tolylterpyridine to target telomeres and telomerase. This innovative approach aims to regulate chromosome mis-segregation rates, which can help in the development of more effective cancer treatments.
Brand Name:
Piptal (Marion Merrell Dow) is the brand name under which Piperidinium,1-ethyl-3-[(2-hydroxy-2,2-diphenylacetyl)oxy]-1-methyl-, bromide (1:1) is marketed. This brand is associated with the development and distribution of this compound for its various applications in the pharmaceutical industry.
Originator
Piptal ,Merrell National ,US ,1955
Manufacturing Process
N-ethyl-3-chloropiperidine was prepared according to the method of Fuson and Zirkle described in Volume 70, J. Am. Chem. Soc., p 2760. 12.0 g (0.081 mol) of N-ethyl-3-chloropiperidine was mixed with 18.6 g (0.081 mol) of benzilic acid and 80 cc of anhydrous isopropyl alcohol as a solvent. The mixture was refluxed for 72 hours. The solution was then filtered and concentrated at 30 mm of mercury. The concentrate was dissolved in water, acidified with hydrochloric acid and extracted with ether to remove theThe aqueous layer was neutralized with sodium bicarbonate and the product was extracted with ether. The ethereal solution of the product was dried with potassium carbonate, the ether was removed by distillation and the residue was distilled at 0.12 to 0.18 mm of mercury, the BP being 194° to 198°C. A yield of 16.5 g (60% of theoretical) of N-ethyl-3-piperidyl-benzilate was obtained.34 g (0.1 mol) of the basic ester is dissolved in 75 cc of isopropyl alcohol and treated with 9.5 g (0.1 mol) of methyl bromide. The mixture is allowed to stand at room temperature until precipitation is complete. The product is removed by filtration and washed with isopropyl alcohol, yield 33 g, MP 175° to 177°C. On recrystallization from isopropyl alcohol, the MP was raised to 179° to 180°C dec.
Therapeutic Function
Spasmolytic
Check Digit Verification of cas no
The CAS Registry Mumber 125-51-9 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,2 and 5 respectively; the second part has 2 digits, 5 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 125-51:
(5*1)+(4*2)+(3*5)+(2*5)+(1*1)=39
39 % 10 = 9
So 125-51-9 is a valid CAS Registry Number.
InChI:InChI=1/C22H28NO3.BrH/c1-3-23(2)16-10-15-20(17-23)26-21(24)22(25,18-11-6-4-7-12-18)19-13-8-5-9-14-19;/h4-9,11-14,20,25H,3,10,15-17H2,1-2H3;1H/q+1;