125-79-1Relevant articles and documents
Cusic
, p. 3546 (1949)
(R)-6-(DIMETHYLAMINO)-4,4-DIPHENYLHEPTAN-3-ONE
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Paragraph 0028-0049, (2014/12/09)
(R)-6-(dimethylamino)-4,4-diphenylheptan-3-one and a process to produce thereof.
(R)-6-(DIMETHYLAMINO)-4,4-DIPHENYLHEPTAN-3-ONE
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Page/Page column 4; 7, (2013/06/06)
Methods for producing methadone and its resolution to produce (R)-6-dimethylamino-4,4-diphenylheptan-3-one ((R)- methadone). Such methods producing first the precursor compound 4-(dimethylamino)-2,2-diphenylpentanitrile. Oxidation of 4-(dimethylamino)-2,2-diphenylpentanitrile with ethyl magnesium halide and hydrolysis with of the complex to form 6-dimethylamino-4,4-diphenylheptan-3-one. Resolution to the (R)-isomer is effected by reaction with a bromocamphor salt. Once isolated the (R)-isomer is crystallised.