1250231-35-6

Basic information

• Product Name: 3,4-difluoro-N-(prop-2-ynyl)benzamide
• Synonyms: 3,4-difluoro-N-(prop-2-ynyl)benzamide
• CAS NO: 1250231-35-6
• Molecular Weight: 195.168
• Mol File: 1250231-35-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 3,4-difluoro-N-(prop-2-ynyl)benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4-difluoro-N-(prop-2-ynyl)benzamide(1250231-35-6)
• EPA Substance Registry System: 3,4-difluoro-N-(prop-2-ynyl)benzamide(1250231-35-6)

Safety Data

• Hazardous Substances Data: 1250231-35-6(Hazardous Substances Data)

Upstream product

• 76903-88-3 3,4-difluorobenzoyl chloride 
• 2450-71-7 Propargylamine 

Downstream Products

• 1310419-29-4 3-(4-((3,4-difluorobenzamido)methyl)-1H-1,2,3-triazol-1-yl)-2-(R,S)-hydroxypropyl 2,3,4,6-tetra-O-acetyl-α-D-galactopyranoside 
• 1310419-31-8 3-(4-((3,4-difluorobenzamido)methyl)-1H-1,2,3-triazol-1-yl)-2-(R,S)-hydroxypropyl α-D-galactopyranoside 

Relevant articles and documents

Palladium-Catalyzed Cascade Difluoroalkylation/Cyclization of N-Propargylamides: Synthesis of Oxazoles and Oxazolines

A palladium-catalyzed process to construct oxazoles and oxazolines with broad functional-group tolerance has been developed, and the method introduces difluoromethyl groups into heterocycles in a one-pot fashion. This system uses a carbonyl oxygen as the acceptor for the addition of a vinylpalladium intermediate to achieve the cyclization. Oxazoline derivatives are generated as the Z-isomer with high stereoselectivity. Additionally, we validated the tentative mechanism of this reaction.