125049-29-8

Basic information

• Product Name: C₃₀H₃₁BrN₂O₃
• CAS NO: 125049-29-8
• Molecular Weight: 547.492
• Mol File: 125049-29-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₃₀H₃₁BrN₂O₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₃₀H₃₁BrN₂O₃(125049-29-8)
• EPA Substance Registry System: C₃₀H₃₁BrN₂O₃(125049-29-8)

Safety Data

• Hazardous Substances Data: 125049-29-8(Hazardous Substances Data)

Upstream product

• 125025-17-4 3-bromo-5-methyl-5H-dibenzocyclohepten-5-ol 
• 125025-21-0 3-bromo-5-methyl-5-(hydroxyamino)-5H-dibenzocycloheptane 
• 3979-65-5 3-bromo-5H-dibenzo[a,d]cyclohepten-5-one 
• 87747-42-0 12-hydroxy-3-bromo-5-methyl-10,11-dihydro-5H-dibenzocyclohepten-5,10-imine 
• 111305-45-4 3-bromo-10,11-dihydro-5-methyl-5H-dibenzo[a,d]-cyclohepten-5,10-imine 
• 13734-34-4 N-tert-butoxycarbonyl-L-phenylalanine 

Downstream Products

• 125134-19-2 (5R,10S)-(-)-3-bromo-10,11-dihydro-5-methyl-5H-dibenzocyclohepten-5,10-imine 
• 125134-28-3 (5S,10R)-(+)-3-bromo-10,11-dihydro-5-methyl-5H-dibenzocyclohepten-5,10-imine 
• 125049-28-7 (5S,10R)-L-phenylalanyl-3-bromo-10,11-dihydro-5-methyl-5H-dibenzocyclohepten-5,10-imine 
• 125134-85-2 (5R,10S)-L-phenylalanyl-3-bromo-10,11-dihydro-5-methyl-5H-dibenzocyclohepten-5,10-imine 

Relevant articles and documents

Synthesis and Pharmacological Evaluation of a Series of Dibenzocycloalkenimines as N-Methyl-D-aspartate Antagonists

A series of 73 dibenzocycloalkenimines were synthesized and evaluated for their ability to displace (+)-10,11-dihydro-5-methyl-5H-dibenzocyclohepten-5,10-imine (-(+)-10) from its specific binding site on rat cortical membranes.A number of the more active compounds (Ki ranging from 0.006 to 0.21 μM) were evaluated for N-methyl-D-aspartate (NMDA) antagonist activity in the rat cortical slice (Kb ranging from 0.08 to 0.9 μM) and anticonvulsant activity in the mouse against NMDA induced convulsions.The ED50 values ranged from 0.22 to 7.76 mg/kg and correlated reasonably well with the Kb determination.In the dibenzocyclohepten-5,10-imine series, the (+)-5S,10R enantiomer displayed consistently higher leves of biological activity.While substitution at the 3-position of (+)-10 with electronegative atoms generally increased in vitro activity, a loss of potency relative to (+)-10 (MK-801) was observed in vivo for all of the compounds tested.