125059-55-4Relevant articles and documents
Synthesis of Azabicyclic Pyrazine Derivatives as Muscarinic Agonists and the Preparation of a Chloropyrazine Analogue with Functional Selectivity at Sub-types of the Muscarinic Receptor
Baker, Raymond,Street, Leslie J.,Reeve, Austin J.,Saunders, John
, p. 760 - 762 (1991)
The synthesis of quinuclidine and azanorbornyl pyrazine derivatives has yielded highly potent and efficacious muscarinic agonists; chloro-substitution in the pyrazine ring of the quinuclidine analogue resulted in the formation of a derivative with both enantiomers displaying partial agonist character but, more importantly, functional selectivity at the M1, M2 and M3 sub-types of the muscarinic receptor.
