125209-79-2Relevant articles and documents
First synthesis of 3-mercapto-2(1H)-pyridinone, a simple disubstituted pyridine useful for synthesis of the 4-azaphenoxathiine ring system and its novel diazaphenoxathiine analogs: 1,6-Diazaphenoxathiine and 2,6-diazaphenoxathiine
Smith, Keith,Anderson, Dorian,Matthews, Ian
, p. 662 - 665 (1996)
3-Mercapto-2(1H)-pyridinone (1) can be synthesized in three simple high-yielding steps from readily available 2-tert-butylthiazolo[4,5-b]pyridine (2). Its disodium salt condenses with o-chloronitrobenzene, 2-chloro-3-nitropyridine, and 3-chloro-4-nitropyridine 1-oxide to give respectively 4-azaphenoxathiine (10), 1,6-diazaphenoxathiine (12), and 2,6-diazaphenoxathiine 2-oxide (14) which reduces to 2,6-diazaphenoxathiine (15). The structures of these previously unreported azaphenoxathiine systems were confirmed by assignment of their respective 13C NMR spectra.
CARBACEPHEM β-LACTAM ANTIBIOTICS
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Page/Page column 94-95, (2009/05/30)
Carbacephem β-lactam antibiotics having the following chemical structures (I) and (II) are disclosed, including stereoisomers, pharmaceutically acceptable salts, esters and prodrugs thereof, wherein Ar2, R1, R2 and R3 are as defined herein. The compounds are useful for the treatment of bacterial infections, in particular those caused by methicillin-resistant Staphylococcus spp.