125228-47-9

Basic information

• Product Name: 2-<2-(<1,3>-dioxolan-2-ylmethyl)piperidin-1-yl>-2-phenylethanol
• Synonyms: 2-<2-(<1,3>-dioxolan-2-ylmethyl)piperidin-1-yl>-2-phenylethanol
• CAS NO: 125228-47-9
• Molecular Weight: 291.39
• Mol File: 125228-47-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-<2-(<1,3>-dioxolan-2-ylmethyl)piperidin-1-yl>-2-phenylethanol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-<2-(<1,3>-dioxolan-2-ylmethyl)piperidin-1-yl>-2-phenylethanol(125228-47-9)
• EPA Substance Registry System: 2-<2-(<1,3>-dioxolan-2-ylmethyl)piperidin-1-yl>-2-phenylethanol(125228-47-9)

Safety Data

• Hazardous Substances Data: 125228-47-9(Hazardous Substances Data)

Upstream product

• 156472-68-3 (3R,5R,8aR)-5-[1,3]Dioxolan-2-ylmethyl-3-phenyl-hexahydro-oxazolo[3,2-a]pyridine-5-carbonitrile 
• 125228-46-8 (3R,8aR)-5-[1,3]Dioxolan-2-ylmethyl-3-phenyl-hexahydro-oxazolo[3,2-a]pyridine-5-carbonitrile 
• 88056-92-2 (-)-2-cyano-6-phenyloxazolopiperidine 

Relevant articles and documents

Concise and stereoselective syntheses of the eight natural ant defense alkaloids (+)-tetraponerine-1 to (+)-tetraponerine-8 according to the CN(R,S) strategy

The asymmetric syntheses of all the known defense alkaloids of the ant Tetraponera sp. tetraponerines T-1 to T-8 have been accomplished in five or six steps with 20-45% overall yields. The synthesis involved in the cross-condensation of (R)-piperidin-2-ylacetaldehyde with 4-aminobutyraldehyde which upon quenching by cyanide ion gave a stable tricyclic amino nitrile 3 with both a high yield and complete diastereoselectivity. This amino nitrile is the common precursor of four tetraponerines. A similar synthesis using (R)-pyrrolidine-2-ylacetaldehyde provided the tricyclic amino nitrile 2 precursor of the four other tetraponerines.