1252553-69-7Relevant articles and documents
Accessing new materials through polymerization and modification of a polycarbonate with a pendant activated ester
Engler, Amanda C.,Chan, Julian M. W.,Coady, Daniel J.,O'Brien, Jeannette M.,Sardon, Haritz,Nelson, Alshakim,Sanders, Daniel P.,Yang, Yi Yan,Hedrick, James L.
, p. 1283 - 1290 (2013)
Functionalized polycarbonates were synthesized by organocatalytic ring-opening polymerization (ROP) of a cyclic monomer with a pendant activated ester (MTC-OC6F5) followed by a postpolymerization modification with both small molecules and macromolecules. Controlled ROP to form homopolymers and diblock copolymers was realized using catalytic quantities of triflic acid. For the homopolymers, a linear relationship between [M] 0/[I]0 and molecular weight (by GPC) demonstrated the living nature of the polymerization. Poly(MTC-OC6F5) was functionalized under mild reaction conditions with a variety of amines to obtain polymers with pendant primary, secondary, and tertiary amides. Graft polymers with a high grafting density of over 87% were synthesized using amine-terminated poly(ethylene glycol) of two different molecular weights (2 and 5 kDa). The preparation of poly(MTC-OC6F5) provides a means of accessing a wide range of functional polycarbonates with minimal synthetic steps. This new methodology for the formation of functionalized polycarbonates provides a simple and versatile platform for the synthesis of new and innovative materials.
VITAMIN FUNCTIONALIZED GEL-FORMING BLOCK COPOLYMERS FOR BIOMEDICAL APPLICATIONS
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Paragraph 0636; 0637, (2018/05/17)
Gel-forming block copolymers were prepared comprising i) a central hydrophilic block consisting essentially of a divalent poly(ethylene oxide) chain and ii) two peripheral monocarbonate or polycarbonate hydrophobic blocks linked to the central block by li
BIODEGRADABLE ORGANIC RADICAL-FUNCTIONALIZED POLYCARBONATES FOR MEDICAL APPLICATIONS
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Paragraph 0230; 0231, (2016/08/29)
Paramagnetic, amphiphilic, biocompatible polymers were prepared comprising a carbonate repeat unit bearing a paramagnetic organic radical, more specifically a nitroxyl radical. The radical polymers can be produced in one step from a precursor polymer bearing an active ester side chain by treating the precursor polymer with a radical-bearing nucleophile. The precursor polymer can be prepared by organocatalyzed catalyzed ring opening polymerization (ROP) of a cyclic carbonate monomer bearing an active ester side chain. The radical polymers can be non-toxic and partially biodegradable. The radical polymers have utility as contrast enhancing agents in a medical imaging application and/or as therapeutic agents for treating a medical condition. The radical polymers can also serve as carriers for therapeutic agents (e.g., drugs) and/or medical image enhancing agents (e.g., NIRF dyes).
